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Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses

Liu, Yan and Shen, Yuecheng and Ruan, Haowen and Brodie, Frank L. and Wong, Terence T. W. and Yang, Changhuei and Wang, Lihong V. (2018) Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses. Journal of Biomedical Optics, 23 (1). Art. No. 010501. ISSN 1083-3668. PMCID PMC5762002.

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Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first several weeks of life, but this surgery risks a host of complications, which can be equally visually disabling. Here, we investigated the feasibility of focusing light noninvasively through highly scattering cataractous lenses to stimulate the retina, thereby preventing amblyopia. This approach would allow the cataractous lens removal surgery to be delayed and hence greatly reduce the risk of complications from early surgery. Employing a wavefront shaping technique named time-reversed ultrasonically encoded optical focusing in reflection mode, we focused 532-nm light through a highly scattering ex vivo adult human cataractous lens. This work demonstrates a potential clinical application of wavefront shaping techniques.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Liu, Yan0000-0002-5837-4908
Shen, Yuecheng0000-0003-1990-8142
Wong, Terence T. W.0000-0001-6399-758X
Yang, Changhuei0000-0001-8791-0354
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2018 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 170709LR received Nov. 2, 2017; accepted for publication Dec. 1, 2017; published online Jan. 10, 2018. We thank Dr. Creig Hoyt, Mr. Joshua Brake, and Mr. Ashton Hemphill for helpful discussion. This work was supported by the National Institutes of Health (DP1 EB016986 to L.V.W. and U01 NS090577 to C.Y.). The authors have no relevant financial interests in this article and no potential conflicts of interest to disclose.
Funding AgencyGrant Number
NIHDP1 EB016986
NIHU01 NS090577
Subject Keywords:focusing light through turbid media; wavefront shaping; adaptive optics; optical phase conjugation; time-reversed ultrasonically encoded optical focusing; cataract; amblyopia
Issue or Number:1
PubMed Central ID:PMC5762002
Record Number:CaltechAUTHORS:20180116-102559459
Persistent URL:
Official Citation:Yan Liu, Yuecheng Shen, Haowen Ruan, Frank L. Brodie, Terence T. W. Wong, Changhuei Yang, Lihong V. Wang, "Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses," J. Biomed. Opt. 23(1) 010501 (10 January 2018)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84340
Deposited By: Tony Diaz
Deposited On:17 Jan 2018 18:52
Last Modified:09 Mar 2020 13:19

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