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Technologies for personalizing cancer immunotherapies

Peng, Songming and Zaretsky, Jesse and Bethune, Michael and Hsu, Alice and Heath, John E. and Noh, Won Jun and Esswein, Shannon and Ribas, Antoni and Baltimore, David and Heath, James R. (2017) Technologies for personalizing cancer immunotherapies. Cancer Immunology Research, 5 (S3). IA17. ISSN 2326-6066. https://resolver.caltech.edu/CaltechAUTHORS:20180117-161110844

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Abstract

At the heart of most cancer immunotherapies are the specific interactions between tumor-infiltrating T cells, and the antigens that attract those T cells into the tumor. It has become increasingly apparent that (mutation containing) neoantigens likely play an important role in this regard. Putative neoantigens are identified by tumor exome analysis, but finding which of those candidates actually promote T cell tumor infiltration is challenging, as is pairing such antigens with the cognate T cell receptor (TCR) genes. Technologies that can address this challenge can help pave the way for personalized immunotherapies. For example, the active neoantigens can be engineered into personalized cell-based cancer vaccines, while the cognate TCRs represent engineered T cell therapy opportunities. I will discuss a nanotech/microchip tool that we have recently developed to address this challenge. The platform allows for the non-destructive enumeration of neoantigen specific T cell populations from either tumor infiltrating lymphocytes (TILs) or unexpanded peripheral blood mononuclear cells (PBMCs), beginning with as few as 10,000 CD8+ cells. I will discuss the application of the platform for kinetic studies of patient responses to checkpoint inhibitor therapy (via blood analysis), as well as applications for matching neoantigen-specificity with T cell receptor genes. I will also discuss how the resultant data can be used to guide the refinement of neoantigen prediction algorithms.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1158/2326-6074.TUMIMM16-IA17 DOIArticle
http://cancerimmunolres.aacrjournals.org/content/5/3_Supplement/IA17PublisherArticle
ORCID:
AuthorORCID
Peng, Songming0000-0002-2742-6584
Baltimore, David0000-0001-8723-8190
Heath, James R.0000-0001-5356-4385
Additional Information:© 2017 American Association for Cancer Research.
Issue or Number:S3
Record Number:CaltechAUTHORS:20180117-161110844
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180117-161110844
Official Citation:Songming Peng, Jesse Zaretsky, Michael Bethune, Alice Hsu, John E. Heath, Won Jun Noh, Shannon Esswein, Antoni Ribas, David Baltimore, James R. Heath. Technologies for personalizing cancer immunotherapies. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2016 Oct 20-23; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2017;5(3 Suppl):Abstract nr IA17.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84377
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Jan 2018 00:43
Last Modified:03 Oct 2019 19:17

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