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Functionalized Ultrasound-Propelled Magnetically Guided Nanomotors: Toward Practical Biomedical Applications

Garcia-Gradilla, Victor and Orozco, Jahir and Sattayasamitsathit, Sirilak and Soto, Fernando and Kuralay, Filiz and Pourazary, Ashley and Katzenberg, Adlai and Gao, Wei and Shen, Yufeng and Wang, Joseph (2013) Functionalized Ultrasound-Propelled Magnetically Guided Nanomotors: Toward Practical Biomedical Applications. ACS Nano, 7 (10). pp. 9232-9240. ISSN 1936-0851 . http://resolver.caltech.edu/CaltechAUTHORS:20180123-113859293

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Abstract

Magnetically guided ultrasound-powered nanowire motors, functionalized with bioreceptors and a drug-loaded polymeric segment, are described for “capture and transport” and drug-delivery processes. These high-performance fuel-free motors display advanced capabilities and functionalities, including magnetic guidance, coordinated aligned movement, cargo towing, capture and isolation of biological targets, drug delivery, and operation in real-life biological and environmental media. The template-prepared three-segment Au–Ni–Au nanowire motors are propelled acoustically by mechanical waves produced by a piezoelectric transducer. An embedded nickel segment facilitates a magnetically guided motion as well as transport of large “cargo” along predetermined trajectories. Substantial improvement in the speed and power is realized by the controlled concavity formation at the end of the motor nanowire using a sphere lithography protocol. Functionalization of the Au segments with lectin and antiprotein A antibody bioreceptors allows capture and transport of E. coli and S. aureus bacteria, respectively. Potential therapeutic applications are illustrated in connection to the addition of a pH-sensitive drug-loaded polymeric (PPy-PSS) segment. The attractive capabilities of these fuel-free acoustically driven functionalized Au–Ni–Au nanowires, along with the simple preparation procedure and minimal adverse effects of ultrasonic waves, make them highly attractive for diverse in vivo biomedical applications.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/nn403851vDOIArticle
http://pubs.acs.org/doi/abs/10.1021/nn403851vPublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/nn403851vRelated ItemSupporting Information
Additional Information:© 2013 American Chemical Society. Received 24 July 2013. Date accepted 22 August 2013. Published online 23 August 2013. Published in print 22 October 2013. This project received support from the Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense (Grant No. HDTRA1-13-1-0002). V.G. is on leave and acknowledges financial support from Centro de Nanociencias y Nanotecnología UNAM and DGAPA-UNAM fellowship (Mexico). W.G. is a HHMI International Student Research fellow. The authors thank D. Wiitala for his assistance. The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
Defense Threat Reduction Agency (DTRA)HDTRA1-13-1-0002
Universidad National Autonoma de Mexico (UNAM)UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:drug delivery; magnetic; nanomotors; sphere lithography; ultrasound
Record Number:CaltechAUTHORS:20180123-113859293
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180123-113859293
Official Citation:Functionalized Ultrasound-Propelled Magnetically Guided Nanomotors: Toward Practical Biomedical Applications Victor Garcia-Gradilla, Jahir Orozco, Sirilak Sattayasamitsathit, Fernando Soto, Filiz Kuralay, Ashley Pourazary, Adlai Katzenberg, Wei Gao, Yufeng Shen, and Joseph Wang ACS Nano 2013 7 (10), 9232-9240 DOI: 10.1021/nn403851v
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84474
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:23 Jan 2018 22:14
Last Modified:31 Jan 2018 00:25

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