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Cargo-Towing Fuel-Free Magnetic Nanoswimmers for Targeted Drug Delivery

Gao, Wei and Kagan, Daniel and Pak, On Shun and Clawson, Corbin and Campuzano, Susana and Chuluun-Erdene, Erdembileg and Shipton, Erik and Fullerton, Eric E. and Zhang, Liangfang and Lauga, Eric and Wang, Joseph (2012) Cargo-Towing Fuel-Free Magnetic Nanoswimmers for Targeted Drug Delivery. Small, 8 (3). pp. 460-467. ISSN 1613-6810. doi:10.1002/smll.201101909. https://resolver.caltech.edu/CaltechAUTHORS:20180126-131405657

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Abstract

Fuel-free nanomotors are essential for future in-vivo biomedical transport and drug-delivery applications. Herein, the first example of directed delivery of drug-loaded magnetic polymeric particles using magnetically driven flexible nanoswimmers is described. It is demonstrated that flexible magnetic nickel–silver nanoswimmers (5–6 μm in length and 200 nm in diameter) are able to transport micrometer particles at high speeds of more than 10 μm s−1 (more than 0.2 body lengths per revolution in dimensionless speed). The fundamental mechanism of the cargo-towing ability of these magnetic (fuel-free) nanowire motors is modelled, and the hydrodynamic features of these cargo-loaded motors discussed. The effect of the cargo size on swimming performance is evaluated experimentally and compared to a theoretical model, emphasizing the interplay between hydrodynamic drag forces and boundary actuation. The latter leads to an unusual increase of the propulsion speed at an intermediate particle size. Potential applications of these cargo-towing nanoswimmers are demonstrated by using the directed delivery of drug-loaded microparticles to HeLa cancer cells in biological media. Transport of the drug carriers through a microchannel from the pick-up zone to the release microwell is further illustrated. It is expected that magnetically driven nanoswimmers will provide a new approach for the rapid delivery of target-specific drug carriers to predetermined destinations.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/smll.201101909DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/smll.201101909/abstractPublisherArticle
http://onlinelibrary.wiley.com/doi/10.1002/smll.201101909/suppinfoPublisherSupporting Information
ORCID:
AuthorORCID
Gao, Wei0000-0002-8503-4562
Additional Information:© 2012 Wiley. Received: September 14, 2011. Published online: December 15, 2011. This work was supported by the National Science Foundation (Award Number CBET-0853375 to JW, CBET-0746285 to EL and CMMI-1031239 to LZ) and the Croucher Foundation (through a scholarship to OSP). SC acknowledges the support from Programa Becas Complutense del Amo (2010-2011). The authors would like to acknowledge also K. Chan for helping the magnetic setup and Allen Pei, Adam Ponedal for assisting in the nanowires preparation.
Funders:
Funding AgencyGrant Number
NSFCBET-0853375
NSFCMMI-1031239
NSFCMMI-1031239
Croucher FoundationUNSPECIFIED
Programa Becas Complutense del Amo (2010-2011)UNSPECIFIED
Issue or Number:3
DOI:10.1002/smll.201101909
Record Number:CaltechAUTHORS:20180126-131405657
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180126-131405657
Official Citation:Gao, W., Kagan, D., Pak, O. S., Clawson, C., Campuzano, S., Chuluun-Erdene, E., Shipton, E., Fullerton, E. E., Zhang, L., Lauga, E. and Wang, J. (2012), Cargo-Towing Fuel-Free Magnetic Nanoswimmers for Targeted Drug Delivery. Small, 8: 460–467. doi: 10.1002/smll.201101909
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84545
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:31 Jan 2018 19:47
Last Modified:15 Nov 2021 20:20

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