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Mass spectrometry using nanomechanical systems: beyond the point-mass approximation

Sader, John E. and Hanay, M. Selim and Neumann, Adam P. and Roukes, Michael L. (2018) Mass spectrometry using nanomechanical systems: beyond the point-mass approximation. Nano Letters, 18 (3). pp. 1608-1614. ISSN 1530-6984. doi:10.1021/acs.nanolett.7b04301.

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The mass measurement of single molecules, in real time, is performed routinely using resonant nanomechanical devices. This approach models the molecules as point particles. A recent development now allows the spatial extent (and, indeed, image) of the adsorbate to be characterized using multimode measurements (Hanay, M. S., Nature Nanotechnol., 10, 2015, pp 339−344). This “inertial imaging” capability is achieved through virtual re-engineering of the resonator’s vibrating modes, by linear superposition of their measured frequency shifts. Here, we present a complementary and simplified methodology for the analysis of these inertial imaging measurements that exhibits similar performance while streamlining implementation. This development, together with the software that we provide, enables the broad implementation of inertial imaging that opens the door to a range of novel characterization studies of nanoscale adsorbates.

Item Type:Article
Related URLs:
URLURL TypeDescription Information
Sader, John E.0000-0002-7096-0627
Hanay, M. Selim0000-0002-1928-044X
Roukes, Michael L.0000-0002-2916-6026
Additional Information:© 2018 American Chemical Society. Received: October 7, 2017; Revised: January 13, 2018; Published: January 25, 2018. The authors acknowledge support from an NIH Director’s Pioneer award, the Australian Research Council grants scheme, and the ARC Centre of Excellence in Exciton Science (CE170100026). M.S.H. acknowledges support from FP7 Marie Curie Career Integration Grant. The authors thank Mustafa Kara for useful discussion. The authors declare no competing financial interest.
Funding AgencyGrant Number
Australian Research CouncilCE170100026
Marie Curie FellowshipUNSPECIFIED
Subject Keywords:Nanomechanical systems, mass spectrometry, inertial imaging, frequency-shift detection
Issue or Number:3
Record Number:CaltechAUTHORS:20180129-091128726
Persistent URL:
Official Citation:Mass Spectrometry Using Nanomechanical Systems: Beyond the Point-Mass Approximation. John E. Sader, M. Selim Hanay, Adam P. Neumann, and Michael L. Roukes. Nano Letters 2018 18 (3), 1608-1614. DOI: 10.1021/acs.nanolett.7b04301
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84557
Deposited By: Tony Diaz
Deposited On:30 Jan 2018 13:34
Last Modified:15 Nov 2021 20:20

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