CaltechAUTHORS
  A Caltech Library Service

Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder

Needham, Brittany D. and Tang, Weiyi and Wu, Wei-Li (2018) Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Developmental Neurobiology, 78 (5). pp. 474-499. ISSN 1932-8451. https://resolver.caltech.edu/CaltechAUTHORS:20180207-090527147

[img] PDF - Accepted Version
See Usage Policy.

1MB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20180207-090527147

Abstract

Social impairment is one of the major symptoms in multiple psychiatric disorders, including autism spectrum disorder (ASD). Accumulated studies indicate a crucial role for the gut microbiota in social development, but these mechanisms remain unclear. This review focuses on two strategies adopted to elucidate the complicated relationship between gut bacteria and host social behavior. In a top-down approach, researchers have attempted to correlate behavioral abnormalities with altered gut microbial profiles in rodent models of ASD, including BTBR mice, maternal immune activation (MIA), maternal valproic acid (VPA) and maternal high-fat diet (MHFD) offspring. In a bottom-up approach, researchers use germ-free (GF) animals, antibiotics, probiotics or pathogens to manipulate the intestinal environment and ascertain effects on social behavior. The combination of both approaches will hopefully pinpoint specific bacterial communities that control host social behavior. Further discussion of how brain development and circuitry is impacted by depletion of gut microbiota is also included. The converging evidence strongly suggests that gut microbes affect host social behavior through the alteration of brain neural circuits. Investigation of intestinal microbiota and host social behavior will unveil any bidirectional communication between the gut and brain and provide alternative therapeutic targets for ASD.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/dneu.22581DOIArticle
ORCID:
AuthorORCID
Needham, Brittany D.0000-0002-0280-1886
Tang, Weiyi0000-0002-1279-1001
Wu, Wei-Li0000-0003-2610-1881
Alternate Title:Searching for the gut microbial contributing factors to social behavior in rodent models
Additional Information:© 2018 Wiley Periodicals, Inc. Issue Online 12 April 2018; Version of Record online: 20 February 2018; Accepted manuscript online: 07 February 2018; Manuscript accepted: 08 January 2018; Manuscript revised: 07 November 2017; Manuscript received: 01 September 2017. The authors apologize to colleagues whose work could not be included in this review due to space considerations. We thank Sarkis K. Mazmanian for support and encouragement on this review. Related research in the Mazmanian laboratory is funded by grants from the NIH (MH100556, DK078938, and NS085910), DARPA, the Heritage Medical Research Institute, Autism Speaks and the Simons Foundation.
Group:Heritage Medical Research Institute
Funders:
Funding AgencyGrant Number
NIHMH100556
NIHDK078938
NIHNS085910
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Heritage Medical Research InstituteUNSPECIFIED
Autism SpeaksUNSPECIFIED
Simons FoundationUNSPECIFIED
Subject Keywords:Autism spectrum disorder (ASD); Gut microbiota; Gut-brain axis; Social behavior; Germ-free (GF)
Issue or Number:5
Record Number:CaltechAUTHORS:20180207-090527147
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180207-090527147
Official Citation:Needham, B. D., Tang, W. and Wu, W. (2018), Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Devel Neurobio, 78: 474-499. doi:10.1002/dneu.22581
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84708
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Feb 2018 17:13
Last Modified:25 Nov 2020 18:48

Repository Staff Only: item control page