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Discovery of Hypocretin/Orexin Ushers in a New Era of Sleep Research

Prober, David A. (2018) Discovery of Hypocretin/Orexin Ushers in a New Era of Sleep Research. Trends in Neurosciences, 41 (2). pp. 70-72. ISSN 0166-2236. PMCID PMC5805467. https://resolver.caltech.edu/CaltechAUTHORS:20180212-094508465

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Abstract

Prior to the 21st century, genetic mechanisms that regulate sleep were largely unknown. In 1998, de Lecea et al. [1] (Proc. Natl. Acad. Sci. U. S. A. 1998; 95:322–327) and Sakurai et al. [2] (Cell 1998; 92: 573–585) reported the discovery of a gene they named hypocretin and orexin, respectively, which led to a revolution in our understanding of genetic and neuronal mechanisms that regulate sleep.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.tins.2017.11.007DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805467PubMed CentralArticle
ORCID:
AuthorORCID
Prober, David A.0000-0002-7371-4675
Additional Information:© 2017 Elsevier Ltd. Available online 6 February 2018.
Subject Keywords:sleep; arousal; hypocretin; orexin
Issue or Number:2
PubMed Central ID:PMC5805467
Record Number:CaltechAUTHORS:20180212-094508465
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180212-094508465
Official Citation:David A. Prober, Discovery of Hypocretin/Orexin Ushers in a New Era of Sleep Research, Trends in Neurosciences, Volume 41, Issue 2, February 2018, Pages 70-72, ISSN 0166-2236, https://doi.org/10.1016/j.tins.2017.11.007. (https://www.sciencedirect.com/science/article/pii/S0166223617302345)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84785
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Feb 2018 18:52
Last Modified:13 Apr 2020 17:37

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