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Alterations in membrane surfaces induced by attachment of carbohydrates

Goodrich, Raymond P. and Crowe, John H. and Crowe, Lois M. and Baldeschwieler, John D. (1991) Alterations in membrane surfaces induced by attachment of carbohydrates. Biochemistry, 30 (21). pp. 5313-5318. ISSN 0006-2960. https://resolver.caltech.edu/CaltechAUTHORS:20180212-100837449

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Abstract

We have examined the behavior of the dry phospholipid dipalmitoylphosphatidylcholine (DPPC) in the presence of several carbohydrate derivatives. These carbohydrate derivatives possess a hydrophobic portion which is incorporated directly into the DPPC membrane and a hydrophilic portion which places the carbohydrate structure at the membrane interface with the surrounding matrix. In the presence of these derivatives, the physical properties of the membrane are altered. These alterations are evident in changes observed in the phosphate and carbonyl vibrational modes of the phospholipid portion of the membrane. In addition, the phase transition behavior of the lipid is significantly altered as evidenced by a reduction in the gel to liquid-crystalline phase transition temperature. These results are consistent with those Previously reported for free carbohydrates interacting with membranes in which a water replacement hypothesis has been used to explain the behavior. The attachment of carbohydrates to the membrane enhances these effects by localizing the agent responsible for these alterations at the membrane interface.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/bi00235a026DOIArticle
https://pubs.acs.org/doi/10.1021/bi00235a026PublisherArticle
Additional Information:© 1991 American Chemical Society. Published in print 28 May 1991. This work was supported by a grant from the Army Research Organization (DAAG-29-83-K-0128). R.P.G. is supported by a National Research Service Award (T32 GM07616) from the National Institute of General Medical Sciences. This work was also supported in part by a grant from Monsanto.
Funders:
Funding AgencyGrant Number
Army Research Office (ARO) DAAG-29-83-K-0128
NIH Predoctoral FellowshipT32 GM07616
National Institute of General Medical SciencesUNSPECIFIED
MonsantoUNSPECIFIED
Issue or Number:21
Record Number:CaltechAUTHORS:20180212-100837449
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180212-100837449
Official Citation:Alterations in membrane surfaces induced by attachment of carbohydrates Raymond P. Goodrich, John H. Crowe, Lois M. Crowe, and John D. Baldeschwieler Biochemistry 1991 30 (21), 5313-5318 DOI: 10.1021/bi00235a026
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84787
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Feb 2018 21:33
Last Modified:03 Oct 2019 19:22

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