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Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices

Narasimhan, Vinayak and Siddique, Radwanul Hasan and Lee, Jeong Oen and Kumar, Shailabh and Ndjamen, Blaise and Du, Juan and Hong, Natalie and Sretavan, David and Choo, Hyuck (2018) Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices. Nature Nanotechnology, 13 (6). pp. 512-519. ISSN 1748-3387. https://resolver.caltech.edu/CaltechAUTHORS:20180214-162837496

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Abstract

Numerous living organisms possess biophotonic nanostructures that provide colouration and other diverse functions for survival. While such structures have been actively studied and replicated in the laboratory, it remains unclear whether they can be used for biomedical applications. Here, we show a transparent photonic nanostructure inspired by the longtail glasswing butterfly (Chorinea faunus) and demonstrate its use in intraocular pressure (IOP) sensors in vivo. We exploit the phase separation between two immiscible polymers (poly(methyl methacrylate) and polystyrene) to form nanostructured features on top of a Si3_N_4 substrate. The membrane thus formed shows good angle-independent white-light transmission, strong hydrophilicity and anti-biofouling properties, which prevent adhesion of proteins, bacteria and eukaryotic cells. We then developed a microscale implantable IOP sensor using our photonic membrane as an optomechanical sensing element. Finally, we performed in vivo testing on New Zealand white rabbits, which showed that our device reduces the mean IOP measurement variation compared with conventional rebound tonometry without signs of inflammation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1038/s41565-018-0111-5DOIArticle
https://rdcu.be/M0MRPublisherFree ReadCube access
ORCID:
AuthorORCID
Narasimhan, Vinayak0000-0003-4165-402X
Siddique, Radwanul Hasan0000-0001-7494-5857
Lee, Jeong Oen0000-0001-5060-8370
Kumar, Shailabh0000-0001-5383-3282
Du, Juan0000-0001-7428-0576
Choo, Hyuck0000-0002-8903-7939
Additional Information:© 2018 Macmillan Publishers Limited, part of Springer Nature. Received: 5 September 2017; Accepted: 6 March 2018; Published online: 30 April 2018. The work was funded by the National Institute of Health (NIH) research grant EY024582 to H.C. and D.S., a HMRI Investigator Award, Caltech CI2 programme, Powell Foundation Award to H.C., and a Research To Prevent Blindness Innovation Award to D.S. Imaging was performed in the Biological Imaging Facility, with the support of the Caltech Beckman Institute and the Arnold and Mabel Beckman Foundation. We acknowledge support from the Beckman Institute of the California Institute of Technology to the Molecular Materials Research Center. These authors contributed equally: Vinayak Narasimhan, Radwanul Hasan Siddique Author Contributions: V.N., R.H.S. and H.C. conceived the study. V.N. and R.H.S. designed the analyses while supervised by H.C. R.H.S. conducted the microscopy and spectroscopy of the longtail glasswing butterfly. R.H.S. conducted the simulations and numerical analysis. V.N. and R.H.S. fabricated and characterized the nanostructured Si3N4-membrane samples. V.N., R.H.S., S.K. and N.H. conducted the in vitro tests. V.N., J.L. and R.H.S. fabricated and characterized the benchtop IOP sensors. V.N., J.L. and J.D. performed the in vivo experiments under the supervision of D.S., V.N. and B.N. conducted the biocompatibility experiments of the in vivo IOP sensors. V.N., R.H.S. and H.C. co-wrote the manuscript with assistance from D.S. All authors discussed the results and commented on the manuscript. Reporting Summary: Further information on experimental design is available in the Nature Research Reporting Summary linked to this article. Data availability: The data that support the plots within this paper and other findings of this study are available from the corresponding authors upon reasonable request. All animals were treated in accordance with the Association for Research in Vision and Ophthalmology (ARVO) Statement for the Use of Animals in Ophthalmic and Vision Research. All animal research was conducted under protocols approved by the Institutional Animal Care and Use Committee of the University of California San Francisco (protocol no. AN110948). The authors declare no competing interests.
Group:Heritage Medical Research Institute
Funders:
Funding AgencyGrant Number
NIHEY024582
Heritage Medical Research InstituteUNSPECIFIED
Caltech Innovation Initiative (CI2)UNSPECIFIED
Charles Lee Powell FoundationUNSPECIFIED
Research to Prevent BlindnessUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20180214-162837496
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180214-162837496
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84841
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Apr 2018 16:47
Last Modified:09 Mar 2020 13:19

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