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Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition

Faraut, Mailys C. M. and Carlson, April A. and Sullivan, Shannon and Tudusciuc, Oana and Ross, Ian and Reed, Chrystal M. and Chung, Jeffrey M. and Mamelak, Adam N. and Rutishauser, Ueli (2018) Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition. Scientific Data, 5 . Art. No. 180010. ISSN 2052-4463. PMCID PMC5810422. http://resolver.caltech.edu/CaltechAUTHORS:20180220-141419391

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Abstract

We present a dataset of 1,576 single neurons recorded from the human amygdala and hippocampus in 65 sessions from 42 patients undergoing intracranial monitoring for localization of epileptic seizures. Subjects performed a recognition memory task with pictures as stimuli. Subjects were asked to identify whether they had seen a particular image the first time (‘new’) or second time (‘old’) on a 1–6 confidence scale. This comprehensive dataset includes the spike times of all neurons and their extracellular waveforms, behavior, electrode locations determined from post-operative MRI scans, demographics, and the stimuli shown. As technical validation, we provide spike sorting quality metrics and assessment of tuning of cells to verify the presence of visually-and memory selective cells. We also provide analysis code that reproduces key scientific findings published previously on a smaller version of this dataset. Together, this large dataset will facilitate the investigation of the neural mechanism of declarative memory by providing a substantial number of hard to obtain human single-neuron recordings during a well characterized behavioral task.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/sdata.2018.10DOIArticle
https://www.nature.com/articles/sdata201810#abstractPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810422PubMed CentralArticle
ORCID:
AuthorORCID
Mamelak, Adam N.0000-0002-4245-6431
Rutishauser, Ueli0000-0002-9207-7069
Additional Information:© 2018 The Authors. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article. Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Received: 12 September 2017. Accepted: 8 December 2017. Published: 13 February 2018. We thank the staff and physicians of the Epilepsy Monitoring Units of the Huntington Memorial Hospital and Cedars-Sinai Medical Center for their support. Acquisition of this dataset has been supported by the National Science Foundation (1554105 to UR), the National Institute of Mental Health (R01MH110831 to UR), the McKnight Endowment for Neuroscience (to UR), a NARSAD Young Investigator grant from the Brain & Behavior Research Foundation (to UR), and an HHMI Summer Medical Fellowship (to SS). Author Contributions: Author contributions are: Performed experiments (U.R., O.T.), data pre-processing, spike sorting and analysis (M.F., U.R., A.C., S.S.), development of analytical tools (U.R.), Neurosurgery (I.R., A.M.), patient care and seizure localization (J.C., C.R.), experimental design (U.R., A.M.), writing of the paper (M.F., U.R.). The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
NSFBCS-1554105
NIHR01MH110831
McKnight Endowment for NeuroscienceUNSPECIFIED
Brain and Behavior Research FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
PubMed Central ID:PMC5810422
Record Number:CaltechAUTHORS:20180220-141419391
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180220-141419391
Official Citation:Faraut, M. C. M. et al. Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition. Sci. Data 5:180010 doi: 10.1038/sdata.2018.10 (2018).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84895
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:22 Feb 2018 04:55
Last Modified:22 Feb 2018 17:46

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