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Hopanoid lipids: from membranes to plant–bacteria interactions

Belin, Brittany J. and Busset, Nicolas and Giraud, Eric and Molinaro, Antonio and Silipo, Alba and Newman, Dianne K. (2018) Hopanoid lipids: from membranes to plant–bacteria interactions. Nature Reviews Microbiology, 16 (5). pp. 304-315. ISSN 1740-1526. PMCID PMC6087623. doi:10.1038/nrmicro.2017.173.

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Lipid research represents a frontier for microbiology, as showcased by hopanoid lipids. Hopanoids, which resemble sterols and are found in the membranes of diverse bacteria, have left an extensive molecular fossil record. They were first discovered by petroleum geologists. Today, hopanoid-producing bacteria remain abundant in various ecosystems, such as the rhizosphere. Recently, great progress has been made in our understanding of hopanoid biosynthesis, facilitated in part by technical advances in lipid identification and quantification. A variety of genetically tractable, hopanoid-producing bacteria have been cultured, and tools to manipulate hopanoid biosynthesis and detect hopanoids are improving. However, we still have much to learn regarding how hopanoid production is regulated, how hopanoids act biophysically and biochemically, and how their production affects bacterial interactions with other organisms, such as plants. The study of hopanoids thus offers rich opportunities for discovery.

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Newman, Dianne K.0000-0003-1647-1918
Additional Information:© 2018 Macmillan Publishers Limited, part of Springer Nature. Published online: 19 February 2018. The authors thank A. Session, P. Normand and the reviewers for constructive comments on the manuscript. We appreciate permission from D. Benson, A. Berry and J. Sáenz to reproduce images from their work. Grants from the Howard Hughes Medical Institute (HHMI; D.K.N.), National Aeronautics and Space Administration (NASA; NNX12AD93G, D.K.N.), the Jane Coffin Childs Memorial Fund (B.J.B.), the US National Institutes of Health (NIH; K99GM126141, B.J.B.), H2020- MSCA-ITN-2014-ETN TOLLerant (A.S.), Progetto Galileo G14-23 (A.S.), Mizutani Foundation for Glycoscience 2014 (A.M.) and the French National Research Agency (ANR-BugsInaCell-13-BSV7-0013) have sustained our research on this problem. Author Contributions: B.J.B, E.G., A.S. and D.K.N. researched data for the article. B.J.B., E.G., A.M., A.S. and D.K.N. substantially contributed to the discussion of content. B.J.B., N.B., E.G., A.S. and D.K.N. wrote the article. All authors reviewed and edited the manuscript before submission. The authors declare no competing financial interests.
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Jane Coffin Childs Memorial FundUNSPECIFIED
European Research Council (ERC)H2020-MSCA-ITN-2014-ETN TOLLerant
Progetto GalileoG14-23
Mizutani Foundation for GlycoscienceUNSPECIFIED
Agence Nationale pour la Recherche (ANR)ANR-BugsInaCell-13-BSV7-0013
Subject Keywords:Bacterial physiology; Membrane lipids; Rhizobial symbiosis
Issue or Number:5
PubMed Central ID:PMC6087623
Record Number:CaltechAUTHORS:20180221-160552040
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84914
Deposited By: Tony Diaz
Deposited On:22 Feb 2018 03:23
Last Modified:15 Nov 2021 20:24

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