Belin, Brittany J. and Busset, Nicolas and Giraud, Eric and Molinaro, Antonio and Silipo, Alba and Newman, Dianne K. (2018) Hopanoid lipids: from membranes to plant–bacteria interactions. Nature Reviews Microbiology, 16 (5). pp. 304-315. ISSN 1740-1526. PMCID PMC6087623. doi:10.1038/nrmicro.2017.173. https://resolver.caltech.edu/CaltechAUTHORS:20180221-160552040
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Abstract
Lipid research represents a frontier for microbiology, as showcased by hopanoid lipids. Hopanoids, which resemble sterols and are found in the membranes of diverse bacteria, have left an extensive molecular fossil record. They were first discovered by petroleum geologists. Today, hopanoid-producing bacteria remain abundant in various ecosystems, such as the rhizosphere. Recently, great progress has been made in our understanding of hopanoid biosynthesis, facilitated in part by technical advances in lipid identification and quantification. A variety of genetically tractable, hopanoid-producing bacteria have been cultured, and tools to manipulate hopanoid biosynthesis and detect hopanoids are improving. However, we still have much to learn regarding how hopanoid production is regulated, how hopanoids act biophysically and biochemically, and how their production affects bacterial interactions with other organisms, such as plants. The study of hopanoids thus offers rich opportunities for discovery.
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Additional Information: | © 2018 Macmillan Publishers Limited, part of Springer Nature. Published online: 19 February 2018. The authors thank A. Session, P. Normand and the reviewers for constructive comments on the manuscript. We appreciate permission from D. Benson, A. Berry and J. Sáenz to reproduce images from their work. Grants from the Howard Hughes Medical Institute (HHMI; D.K.N.), National Aeronautics and Space Administration (NASA; NNX12AD93G, D.K.N.), the Jane Coffin Childs Memorial Fund (B.J.B.), the US National Institutes of Health (NIH; K99GM126141, B.J.B.), H2020- MSCA-ITN-2014-ETN TOLLerant (A.S.), Progetto Galileo G14-23 (A.S.), Mizutani Foundation for Glycoscience 2014 (A.M.) and the French National Research Agency (ANR-BugsInaCell-13-BSV7-0013) have sustained our research on this problem. Author Contributions: B.J.B, E.G., A.S. and D.K.N. researched data for the article. B.J.B., E.G., A.M., A.S. and D.K.N. substantially contributed to the discussion of content. B.J.B., N.B., E.G., A.S. and D.K.N. wrote the article. All authors reviewed and edited the manuscript before submission. The authors declare no competing financial interests. | ||||||||||||||||||
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Subject Keywords: | Bacterial physiology; Membrane lipids; Rhizobial symbiosis | ||||||||||||||||||
Issue or Number: | 5 | ||||||||||||||||||
PubMed Central ID: | PMC6087623 | ||||||||||||||||||
DOI: | 10.1038/nrmicro.2017.173 | ||||||||||||||||||
Record Number: | CaltechAUTHORS:20180221-160552040 | ||||||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180221-160552040 | ||||||||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||||
ID Code: | 84914 | ||||||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||||||
Deposited By: | Tony Diaz | ||||||||||||||||||
Deposited On: | 22 Feb 2018 03:23 | ||||||||||||||||||
Last Modified: | 15 Nov 2021 20:24 |
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