CaltechAUTHORS
  A Caltech Library Service

When Fear Is Near: Threat Imminence Elicits Prefrontal-Periaqueductal Gray Shifts in Humans

Mobbs, Dean and Petrovic, Predrag and Marchant, Jennifer L. and Hassabis, Demis and Weiskopf, Nikolaus and Seymour, Ben and Dolan, Raymond J. and Frith, Christopher D. (2007) When Fear Is Near: Threat Imminence Elicits Prefrontal-Periaqueductal Gray Shifts in Humans. Science, 317 (5841). pp. 1079-1083. ISSN 0036-8075. PMCID PMC2648508. doi:10.1126/science.1144298. https://resolver.caltech.edu/CaltechAUTHORS:20180302-151125026

[img] PDF - Accepted Version
See Usage Policy.

1MB
[img] PDF (Materials and Methods; Figs. S1 to S5; Tables S1 to S5; References) - Supplemental Material
See Usage Policy.

1MB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20180302-151125026

Abstract

Humans, like other animals, alter their behavior depending on whether a threat is close or distant. We investigated spatial imminence of threat by developing an active avoidance paradigm in which volunteers were pursued through a maze by a virtual predator endowed with an ability to chase, capture, and inflict pain. Using functional magnetic resonance imaging, we found that as the virtual predator grew closer, brain activity shifted from the ventromedial prefrontal cortex to the periaqueductal gray. This shift showed maximal expression when a high degree of pain was anticipated. Moreover, imminence-driven periaqueductal gray activity correlated with increased subjective degree of dread and decreased confidence of escape. Our findings cast light on the neural dynamics of threat anticipation and have implications for the neurobiology of human anxiety-related disorders.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/science.1144298DOIArticle
http://www.sciencemag.org/cgi/content/full/317/5841/1079/DC1PublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648508PubMed CentralArticle
ORCID:
AuthorORCID
Mobbs, Dean0000-0003-1175-3772
Dolan, Raymond J.0000-0001-9356-761X
Additional Information:© 2007 American Association for the Advancement of Science. Received 26 April 2007; accepted 10 July 2007.
Issue or Number:5841
PubMed Central ID:PMC2648508
DOI:10.1126/science.1144298
Record Number:CaltechAUTHORS:20180302-151125026
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180302-151125026
Official Citation:When Fear Is Near: Threat Imminence Elicits Prefrontal-Periaqueductal Gray Shifts in Humans. BY DEAN MOBBS, PREDRAG PETROVIC, JENNIFER L. MARCHANT, DEMIS HASSABIS, NIKOLAUS WEISKOPF, BEN SEYMOUR, RAYMOND J. DOLAN, CHRISTOPHER D. FRITH. SCIENCE 24 AUG 2007 : 1079-1083
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85074
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Mar 2018 23:19
Last Modified:15 Nov 2021 20:25

Repository Staff Only: item control page