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Insula and Striatum Mediate the Default Bias

Yu, Rongjun and Mobbs, Dean and Seymour, Ben and Calder, Andrew J. (2010) Insula and Striatum Mediate the Default Bias. Journal of Neuroscience, 30 (44). pp. 14702-14707. ISSN 0270-6474. PMCID PMC6633627. https://resolver.caltech.edu/CaltechAUTHORS:20180305-141504217

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Abstract

Humans are creatures of routine and habit. When faced with situations in which a default option is available, people show a consistent tendency to stick with the default. Why this occurs is unclear. To elucidate its neural basis, we used a novel gambling task in conjunction with functional magnetic resonance imaging. Behavioral results revealed that participants were more likely to choose the default card and felt enhanced emotional responses to outcomes after making the decision to switch. We show that increased tendency to switch away from the default during the decision phase was associated with decreased activity in the anterior insula; activation in this same area in reaction to “switching away from the default and losing” was positively related with experienced frustration. In contrast, decisions to choose the default engaged the ventral striatum, the same reward area as seen in winning. Our findings highlight aversive processes in the insula as underlying the default bias and suggest that choosing the default may be rewarding in itself.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.3772-10.2010DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6633627/PubMed CentralArticle
ORCID:
AuthorORCID
Yu, Rongjun0000-0003-0123-1524
Mobbs, Dean0000-0003-1175-3772
Additional Information:© 2010 the authors. For the first six months after publication SfN’s license will be exclusive. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received July 20, 2010; revised Aug. 30, 2010; accepted Sept. 13, 2010. The research was funded by the United Kingdom Medical Research Council (Grant U1055.02.001.00001.01 to A.J.C.). R.Y. is supported by the UK/China Scholarships for Excellence.
Funders:
Funding AgencyGrant Number
Medical Research Council (UK)U1055.02.001.00001.01
China Scholarship CouncilUNSPECIFIED
Issue or Number:44
PubMed Central ID:PMC6633627
Record Number:CaltechAUTHORS:20180305-141504217
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180305-141504217
Official Citation:Insula and Striatum Mediate the Default Bias Rongjun Yu, Dean Mobbs, Ben Seymour, Andrew J. Calder Journal of Neuroscience 3 November 2010, 30 (44) 14702-14707; DOI: 10.1523/JNEUROSCI.3772-10.2010
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85104
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 Mar 2018 22:26
Last Modified:14 Apr 2020 17:59

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