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Aberrant Neural Function During Emotion Attribution in Female Subjects With Fragile X Syndrome

Hagan, Cindy C. and Hoeft, Fumiko and Mackey, Allyson and Mobbs, Dean and Reiss, Allan L. (2008) Aberrant Neural Function During Emotion Attribution in Female Subjects With Fragile X Syndrome. Journal of the American Academy of Child & Adolescent Psychiatry, 47 (12). pp. 1443-1454. ISSN 0890-8567. PMCID PMC4820328. doi:10.1097/CHI.0b013e3181886e92. https://resolver.caltech.edu/CaltechAUTHORS:20180306-085437018

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Abstract

Objective: Fragile X (FraX) syndrome is caused by mutations of the FraX mental retardation-1 gene—a gene responsible for producing FraX mental retardation protein. The neurocognitive phenotype associated with FraX in female subjects includes increased risk for emotional disorders including social anxiety, depression, and attention deficit. Here, the authors investigated the neurobiological systems underlying emotion attribution in female subjects with FraX syndrome. Method: While undergoing functional magnetic resonance imaging, 10 high-functioning female subjects with FraX syndrome and 10 typically developing (TD) female subjects were presented with photographs of happy, sad, and neutral faces and instructed to determine the facial emotion. Results: No significant group differences were found for the recognition of happy faces, although the FraX group showed a trend toward a significant difference for the recognition of sad faces and significantly poorer recognition of neutral faces. Controlling for between-group differences in IQ and performance accuracy, the TD group had greater activation than the FraX group in the anterior cingulate cortex (ACC) for neutral faces compared with scrambled faces and the caudate for sad faces compared with scrambled faces (but not for sad faces compared with neutral faces). In the FraX group, FraX mental retardation protein levels positively correlated with activation in the dorsal ACC for neutral, happy, and sad faces when independently compared with scrambled faces. Significantly greater negative correlation between IQ and insula activation for neutral faces relative to scrambled faces was observed in the FraX group compared with the TD group. Significantly greater positive correlation between IQ and ACC activation for neutral faces relative to scrambled faces was observed in the TD group compared with the FraX group. Conclusions: Although emotion recognition is generally spared in FraX syndrome, the emotion circuit (i.e., ACC, caudate, insula) that modulates emotional responses to facial stimuli may be disrupted.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1097/CHI.0b013e3181886e92DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820328/PubMed CentralArticle
ORCID:
AuthorORCID
Hagan, Cindy C.0000-0002-4576-7120
Mobbs, Dean0000-0003-1175-3772
Additional Information:© 2008 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. Financial support was provided by NIMH grant #50047 and the Canal Family Research Fund. The authors thank Christa Watson, Stephanie Brogdon, Melissa Hirt, Chris Wagner, Sudharshan Parthasarathy, Nancy Adleman, Jessica Ringel, and Lauren Penniman for assistance with the magnetic resonance imaging scanning and preparation and Jennifer Keller, Cindy K. Johnston, and Amy Lightbody for assistance with cognitive testing. The authors also thank the subjects and their families for participation in this study. The authors report no conflicts of interest.
Funders:
Funding AgencyGrant Number
NIH50047
National Institute of Mental Health (NIMH)UNSPECIFIED
Canal Family Research FundUNSPECIFIED
Subject Keywords:fMRI; fragile X; emotion; cingulate cortex; insula
Issue or Number:12
PubMed Central ID:PMC4820328
DOI:10.1097/CHI.0b013e3181886e92
Record Number:CaltechAUTHORS:20180306-085437018
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180306-085437018
Official Citation:Hagan CC, Hoeft F, Mackey A, Mobbs D, Reiss AL. Aberrant Neural Function During Emotion Attribution in Female Subjects With Fragile X Syndrome. Journal of the American Academy of Child and Adolescent Psychiatry. 2008;47(12):1443-1354. doi:10.1097/CHI.0b013e3181886e92.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85127
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:06 Mar 2018 18:28
Last Modified:15 Nov 2021 20:25

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