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Experimental investigation of the effect of non-Newtonian behavior of blood flow in the Fontan circulation

Cheng, Andrew L. and Pahlevan, Niema M. and Rinderknecht, Derek G. and Wood, John C. and Gharib, Morteza (2018) Experimental investigation of the effect of non-Newtonian behavior of blood flow in the Fontan circulation. European Journal of Mechanics B/Fluids, 68 . pp. 184-192. ISSN 0997-7546. https://resolver.caltech.edu/CaltechAUTHORS:20180307-101927463

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Abstract

The Fontan procedure for univentricular heart defects creates a unique circulation where all pulmonary blood flow is passively supplied directly from systemic veins. Computational simulations, aimed at optimizing the surgery, have assumed blood to be a Newtonian fluid without evaluating the potential error introduced by this assumption. We compared flow behavior between a non-Newtonian blood analog (0.04% xanthan gum) and a control Newtonian fluid (45% glycerol) in a simplified model of the Fontan circulation. Particle image velocimetry was used to examine flow behavior at two different cardiac outputs and two caval blood flow distributions. Pressure and flow rates were measured at each inlet and outlet. Velocity, shear strain, and shear stress maps were derived from velocity data. Power loss was calculated from pressure, flow, and velocity data. Power loss was increased in all test conditions with xanthan gum vs. glycerol (mean 10 ± 2.9% vs. 5.6 ± 1.3%, p=0.032). Pulmonary blood flow distribution differed in all conditions, more so at low cardiac output. Caval blood flow mixing patterns and shear stress were also qualitatively different between the solutions in all conditions. We conclude that assuming blood to be a Newtonian fluid introduces considerable error into simulations of the Fontan circulation, where low-shear flow predominates.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.euromechflu.2017.12.009DOIArticle
https://www.sciencedirect.com/science/article/pii/S099775461730417XPublisherArticle
ORCID:
AuthorORCID
Gharib, Morteza0000-0002-2204-9302
Additional Information:© 2017 Elsevier Masson SAS. Received 20 July 2017, Revised 27 September 2017, Accepted 20 December 2017, Available online 27 December 2017.
Group:GALCIT
Subject Keywords:Congenital heart disease; Fontan; Biofluid dynamics; Non-Newtonian fluid; Wall shear stress
Record Number:CaltechAUTHORS:20180307-101927463
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180307-101927463
Official Citation:Andrew L. Cheng, Niema M. Pahlevan, Derek G. Rinderknecht, John C. Wood, Morteza Gharib, Experimental investigation of the effect of non-Newtonian behavior of blood flow in the Fontan circulation, European Journal of Mechanics - B/Fluids, Volume 68, 2018, Pages 184-192, ISSN 0997-7546, https://doi.org/10.1016/j.euromechflu.2017.12.009. (http://www.sciencedirect.com/science/article/pii/S099775461730417X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85176
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Mar 2018 18:32
Last Modified:03 Oct 2019 19:27

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