A Caltech Library Service

There's (still) plenty of room at the bottom

Olsman, Noah and Goentoro, Lea (2018) There's (still) plenty of room at the bottom. Current Opinion in Biotechnology, 54 . pp. 72-79. ISSN 0958-1669 .

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Motifs, circuits, and networks are core conceptual elements in modern systems and synthetic biology. While there are still undoubtedly more fascinating computations to discover at network level, there are also rich computations that we are only beginning to uncover within the diverse molecules that constitute the networks. Here we explore some work, both new and old, that showcases the incredible computational capacity of seemingly simple molecular mechanisms. A more sophisticated understanding of computations at the molecular level will inspire the development of a more nuanced toolbox for future biological engineering.

Item Type:Article
Related URLs:
URLURL TypeDescription
Goentoro, Lea0000-0002-3904-0195
Additional Information:© 2018 Elsevier Ltd. Available online 10 March 2018. We would like to thank Chris Frick and Tal Einav for insightful feedback and suggestions about the manuscript. This work was supported by the Benjamin M. Rosen Fellowship (NO), James S. McDonnell Scholar Award in Complex Systems 220020365 (to LG), and NSF CAREER Award NSF.145863 (to LG).
Funding AgencyGrant Number
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
James S. McDonnell Foundation220020365
Record Number:CaltechAUTHORS:20180312-084418602
Persistent URL:
Official Citation:Noah Olsman, Lea Goentoro, There's (still) plenty of room at the bottom, Current Opinion in Biotechnology, Volume 54, December 2018, Pages 72-79, ISSN 0958-1669, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85239
Deposited By: Tony Diaz
Deposited On:12 Mar 2018 17:07
Last Modified:12 Mar 2018 17:07

Repository Staff Only: item control page