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Ring-Closing Metathesis and Related Processes in Organic Synthesis

Grubbs, Robert H. and Miller, Scott J. and Fu, Gregory C. (1995) Ring-Closing Metathesis and Related Processes in Organic Synthesis. Accounts of Chemical Research, 28 (11). pp. 446-452. ISSN 0001-4842. doi:10.1021/ar00059a002.

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Carbon-carbon bond forming reactions remain among the most important for the synthesis of organic structures. The transition metal alkylidene-catalyzed olefin metathesis reaction (eq 1) and the related transition metal alkylidene-mediated carbonyl olefination reaction (eq 2) are two such processes. Historically, olefin metathesis has been studied extensively both from the mechanistic standpoint and in the context of polymer synthesis. In contrast, its application to the synthesis of complex organic molecules and natural products has been limited. The related reaction, transition metal-mediated carbonyl olefination, is not as extensively studied mechanistically nor in synthetic applications. Among the reasons for this gap in methodology has been the incompatibility of traditional catalysts with the polar functional groups typically encountered in organic synthesis.

Item Type:Article
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URLURL TypeDescription
Grubbs, Robert H.0000-0002-0057-7817
Fu, Gregory C.0000-0002-0927-680X
Additional Information:© 1995 American Chemical Society. Received May 22, 1995. This research was generously supported by the National Institutes of Health. S.J.M. and G.C.F. are grateful to the NSF for postdoctoral fellowships.
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NSF Postdoctoral FellowshipUNSPECIFIED
Issue or Number:11
Record Number:CaltechAUTHORS:20180315-071849342
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Official Citation:Ring-Closing Metathesis and Related Processes in Organic Synthesis Robert H. Grubbs, Scott J. Miller, and Gregory C. Fu Accounts of Chemical Research 1995 28 (11), 446-452 DOI: 10.1021/ar00059a002
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85320
Deposited By: Ruth Sustaita
Deposited On:16 Mar 2018 15:48
Last Modified:15 Nov 2021 20:27

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