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Poly(amidoamine) Dendrimers: A New Class of High Capacity Chelating Agents for Cu(II) Ions

Diallo, Mamadou S. and Balogh, Lajos and Shafagati, Abdul and Johnson, James H., Jr. and Goddard, William A., III and Tomalia, Donald A. (1999) Poly(amidoamine) Dendrimers: A New Class of High Capacity Chelating Agents for Cu(II) Ions. Environmental Science and Technology, 33 (5). pp. 820-824. ISSN 0013-936X. doi:10.1021/es980521a.

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This communication describes preliminary results of an experimental investigation of the binding of Cu(II) ions to poly(amidoamine) (PAMAM) dendrimers in aqueous solutions. Dendrimers are highly branched polymers with controlled composition and architecture consisting of three structural components:  a core, interior branch cells, and terminal branch cells. PAMAM dendrimers possess functional nitrogen and amide groups arranged in regular “branched upon branched” patterns which are displayed in geometrically progressive numbers as a function of generation level. Terminal groups of PAMAM dendrimers may be any organic substituent such as primary amines, carboxylic groups, etc. In aqueous solutions, PAMAM dendrimers can serve as high capacity nanoscale containers for toxic metal ions such as Cu(II). Compared to traditional chelating agents (e.g., triethylene tetramine) and macrocyles (e.g., cyclams) with nitrogen donors, which can typically bind only one Cu(II) ion per molecule, a generation eight (G8) PAMAM dendrimer can bind up 153 ± 20 Cu(II) ions per molecule. This clearly illustrates a distinct advantage of dendrimers over traditional chelating agents and macrocycles; that is the covalent attachment of nitrogen ligands to conformationally flexible PAMAM chains enclosed within a nanoscopic structure results in a substantial increase in binding capacity.

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Diallo, Mamadou S.0000-0002-2571-1568
Goddard, William A., III0000-0003-0097-5716
Additional Information:© 1999 American Chemical Society. Received for review May 20, 1998. Revised manuscript received December 4, 1998. Accepted December 11, 1998. Publication Date (Web): January 26, 1999. This research was conducted in the Department of Civil Engineering at Howard University (HU) and the ARL/MMI Dendritic Polymers Center of Excellence. Funding was provided by the Army Research Office (ARO) Multi-University Research Initiative on Dendritic Polymers (Caltech), DOE Massie Chair Grant (Howard University), and ARL (MMI). We thank Dr. Douglas Kiserow (ARO), Dr. Gary Hagnauer (ARL), and Ms. Malika Hobbs (DOE) for their constant support.
Funding AgencyGrant Number
Army Research Office (ARO)UNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Army Research LaboratoryUNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20180320-145253228
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Official Citation:Poly(amidoamine) Dendrimers:  A New Class of High Capacity Chelating Agents for Cu(II) Ions. Mamadou S. Diallo, Lajos Balogh, Abdul Shafagati, James H. Johnson, Jr., William A. Goddard, III, and Donald A. Tomalia. Environmental Science & Technology 1999 33 (5), 820-824 DOI: 10.1021/es980521a
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85384
Deposited By: Tony Diaz
Deposited On:02 Apr 2018 20:56
Last Modified:15 Nov 2021 20:28

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