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Implantable phototherapy device to treat diabetic retinopathy

Cook, Colin A. and Martinez-Camarillo, Juan C. and Humayun, Mark S. and Tai, Yu-Chong (2017) Implantable phototherapy device to treat diabetic retinopathy. In: 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS). IEEE , Piscataway, NJ, pp. 393-396. ISBN 978-1-5386-2732-7. https://resolver.caltech.edu/CaltechAUTHORS:20180322-102107647

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Abstract

This paper reports on the first implantable phototherapy device to treat diabetic retinopathy by modulating rod cell metabolism through reduction of dark current. Utilizing a tritium-based radioluminescent light source capable of emitting around 505nm, the device achieves phototherapeutic activity for up to a 12-year service lifetime and <30mm^3 size. The unique scleral anchoring system facilitates simple, rapid, and robust implantation into the eye. Implantation into a rabbit model demonstrated safety over a 4-week period with no adverse effects observed.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/TRANSDUCERS.2017.7994070DOIArticle
http://ieeexplore.ieee.org/document/7994070PublisherArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2017 IEEE. Thanks to the Caltech MEMS Lab members for their guidance with techniques and fabrication. Graduate scholarship provided by Natural Sciences and Engineering Research Council of Canada.
Funders:
Funding AgencyGrant Number
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Record Number:CaltechAUTHORS:20180322-102107647
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180322-102107647
Official Citation:C. A. Cook, J. C. Martinez-Camarillo, M. S. Humayun and Y. C. Tai, "Implantable phototherapy device to treat diabetic retinopathy," 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), Kaohsiung, 2017, pp. 393-396. doi: 10.1109/TRANSDUCERS.2017.7994070 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7994070&isnumber=7993963
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85414
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Mar 2018 21:21
Last Modified:03 Oct 2019 19:30

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