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Proteins, air and water: reporter genes for ultrasound and magnetic resonance imaging

Lu, George J. and Farhadi, Arash and Mukherjee, Arnab and Shapiro, Mikhail G. (2018) Proteins, air and water: reporter genes for ultrasound and magnetic resonance imaging. Current Opinion in Chemical Biology, 45 . pp. 57-63. ISSN 1367-5931. http://resolver.caltech.edu/CaltechAUTHORS:20180322-135005180

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Abstract

A long-standing goal of molecular imaging is to visualize cellular function within the context of living animals, necessitating the development of reporter genes compatible with deeply penetrant imaging modalities such as ultrasound and magnetic resonance imaging (MRI). Until recently, no reporter genes for ultrasound were available, and most genetically encoded reporters for MRI were limited by metal availability or relatively low sensitivity. Here we review how these limitations are being addressed by recently introduced reporter genes based on air-filled and water-transporting biomolecules. We focus on gas-filled protein nanostructures adapted from buoyant microbes, which scatter sound waves, perturb magnetic fields and interact with hyperpolarized nuclei, as well as transmembrane water channels that alter the effective diffusivity of water in tissue.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.cbpa.2018.02.011DOIArticle
https://www.sciencedirect.com/science/article/pii/S1367593117301898PublisherArticle
ORCID:
AuthorORCID
Lu, George J.0000-0002-4689-9686
Farhadi, Arash0000-0001-9137-8559
Mukherjee, Arnab0000-0002-6783-8225
Shapiro, Mikhail G.0000-0002-0291-4215
Additional Information:© 2018 Elsevier Ltd. Available online 14 March 2018. We thank members of the Shapiro Laboratory for helpful discussions. Related work in the Shapiro laboratory is also supported by the Heritage Medical Research Institute, the National Institutes of Health, the Defense Advanced Research Projects Agency, the Jacobs Institute for Molecular Engineering in Medicine, the Caltech Center for Environmental Microbial Interactions, the Human Frontiers Science Program, the Burroughs Wellcome Fund, the Pew Scholarship in the Biomedical Sciences, the Sontag Foundation, the Packard Fellowship for Science and Engineering. A.F. is supported by the Natural Sciences and Engineering Research Council of Canada PGSD. Author contributions: All authors wrote the manuscript. The authors declare no competing financial interests.
Group:Heritage Medical Research Institute, Caltech Center for Environmental Microbial Interactions (CEMI)
Funders:
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
NIHUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Jacobs Institute for Molecular Engineering for MedicineUNSPECIFIED
Caltech Center for Environmental Microbial Interactions (CEMI)UNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
Pew Charitable TrustUNSPECIFIED
Sontag FoundationUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Record Number:CaltechAUTHORS:20180322-135005180
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180322-135005180
Official Citation:George J Lu, Arash Farhadi, Arnab Mukherjee, Mikhail G Shapiro. Proteins, air and water: reporter genes for ultrasound and magnetic resonance imaging. Current Opinion in Chemical Biology, Volume 45, 2018, Pages 57-63, ISSN 1367-5931, https://doi.org/10.1016/j.cbpa.2018.02.011.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85421
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Mar 2018 17:22
Last Modified:26 Mar 2018 17:22

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