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Metal-catalysed Metathesis Reactions for Greener Synthon/Drug Synthesis

dos Santos, E. N. and Granato, A. V. and Santos, A. G. (2018) Metal-catalysed Metathesis Reactions for Greener Synthon/Drug Synthesis. In: Sustainable Synthesis of Pharmaceuticals: Using Transition Metal Complexes as Catalysts. Green Chemistry Series. No.54. Royal Society of Chemistry , pp. 230-252. ISBN 978-1-78262-934-4.

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Olefin metathesis is now an important tool for modern organic synthesis. Ring-closing metathesis is widely employed in drug discovery and in the industrial synthetic routes of some active pharmaceutical ingredients (APIs). Cross metathesis is the technological keystone for bio-refineries based in plant oils, which reveals the large potential of this reaction for greener processes. This chapter provides general information about how to choose a catalyst and the conditions to perform metathesis reactions, as well as some details about the mechanism and catalyst stability. Important examples in API synthesis and the utilization of metathesis in bio-renewables are also presented.

Item Type:Book Section
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Additional Information:© 2018 The Royal Society of Chemistry. The authors thank the Brazilian funding agencies CNPq, CAPES and FAPEMIG for supporting scientific projects on the theme of this chapter.
Funding AgencyGrant Number
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNSPECIFIED
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)UNSPECIFIED
Fundação de Amparo à Pesquisa de MG (FAPEMIG)UNSPECIFIED
Series Name:Green Chemistry Series
Issue or Number:54
Record Number:CaltechAUTHORS:20180327-105240482
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85454
Deposited By: Tony Diaz
Deposited On:27 Mar 2018 18:24
Last Modified:03 Oct 2019 19:31

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