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Biomolecular Ultrasound and Sonogenetics

Maresca, David and Lakshmanan, Anupama and Abedi, Mohamad and Bar-Zion, Avinoam and Farhadi, Arash and Lu, George J. and Szablowski, Jerzy O. and Wu, Di and Yoo, Sangjin and Shapiro, Mikhail G. (2018) Biomolecular Ultrasound and Sonogenetics. Annual Review of Chemical and Biomolecular Engineering, 9 . pp. 229-252. ISSN 1947-5438. PMCID PMC6086606. https://resolver.caltech.edu/CaltechAUTHORS:20180330-152125173

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Abstract

Visualizing and modulating molecular and cellular processes occurring deep within living organisms is fundamental to our study of basic biology and disease. Currently, the most sophisticated tools available to dynamically monitor and control cellular events rely on light-responsive proteins, which are difficult to use outside of optically transparent model systems, cultured cells, or surgically accessed regions owing to strong scattering of light by biological tissue. In contrast, ultrasound is a widely used medical imaging and therapeutic modality that enables the observation and perturbation of internal anatomy and physiology but has historically had limited ability to monitor and control specific cellular processes. Recent advances are beginning to address this limitation through the development of biomolecular tools that allow ultrasound to connect directly to cellular functions such as gene expression. Driven by the discovery and engineering of new contrast agents, reporter genes, and bioswitches, the nascent field of biomolecular ultrasound carries a wave of exciting opportunities.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1146/annurev-chembioeng-060817-084034DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086606PubMed CentralArticle
ORCID:
AuthorORCID
Maresca, David0000-0002-4921-6406
Lakshmanan, Anupama0000-0002-6702-837X
Abedi, Mohamad0000-0001-9717-6288
Bar-Zion, Avinoam0000-0002-7564-9467
Farhadi, Arash0000-0001-9137-8559
Lu, George J.0000-0002-4689-9686
Szablowski, Jerzy O.0000-0001-7851-5408
Wu, Di0000-0002-6848-668X
Yoo, Sangjin0000-0002-0449-4242
Shapiro, Mikhail G.0000-0002-0291-4215
Additional Information:© 2018 Annual Reviews. Review in Advance first posted online on March 26, 2018. The authors are not aware of any affiliations, memberships, funding, or financial holdings that might be perceived as affecting the objectivity of this review. The authors thank members of the Shapiro laboratory and collaborators for helpful discussions. Related work in the Shapiro laboratory is supported by the Heritage Medical Research Institute, the National Institutes of Health, the Defense Advanced Research Projects Agency, the Jacobs Institute for Molecular Engineering in Medicine, the Caltech Center for Environmental Microbial Interactions, the Human Frontiers Science Program, the Burroughs Wellcome Fund, the Pew Scholarship in the Biomedical Sciences, the Sontag Foundation, and the Packard Fellowship for Science and Engineering. D.M. is supported by a postdoctoral fellowship from the Human Frontier Science Program. A.L. and M.A. are supported by the National Science Foundation graduate research fellowship.
Group:Caltech Center for Environmental Microbial Interactions (CEMI), Heritage Medical Research Institute, Rosen Bioengineering Center, Jacobs Institute for Molecular Engineering for Medicine
Funders:
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
NIHUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Jacobs Institute for Molecular Engineering for MedicineUNSPECIFIED
Caltech Center for Environmental Microbial Interactions (CEMI)UNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
Pew Charitable TrustUNSPECIFIED
Sontag FoundationUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
NSF Graduate Research FellowshipUNSPECIFIED
Subject Keywords:biomolecular, ultrasound, sonogenetics, gas vesicles, imaging, reporter gene
PubMed Central ID:PMC6086606
Record Number:CaltechAUTHORS:20180330-152125173
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180330-152125173
Official Citation:Biomolecular Ultrasound and Sonogenetics David Maresca, Anupama Lakshmanan, Mohamad Abedi, Avinoam Bar-Zion, Arash Farhadi, George J. Lu, Jerzy O. Szablowski, Di Wu, Sangjin Yoo, Mikhail G. Shapiro Annual Review of Chemical and Biomolecular Engineering 2018 9:1, 229-252
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85547
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:30 Mar 2018 22:40
Last Modified:22 Nov 2019 21:14

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