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Single-Cell Metabolic Model Determination by Analysis of Microbial Populations

Bailey, James E. (1983) Single-Cell Metabolic Model Determination by Analysis of Microbial Populations. In: Foundations of Biochemical Engineering. ACS Symposium Series. No.207. American Chemical Society , Washington, DC, pp. 135-157. ISBN 9780841207523.

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The properties of microbial populations result from the characteristics of metabolism and its control at the level of the individual cell. Useful descriptions of population behavior may therefore be constructed based on understanding of single-cell metabolism, and, conversely, studies of population properties may be employed to extract information about single-cell operation. Population balance equations provide the primary mathematical tool for these purposes, and flow cytometry allows experimental access to the distribution of cell states in the population. Application of these methods to bacteria and yeasts is illustrated using three example systems.

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Additional Information:© 1983 American Chemical Society. Received July 22, 1982. Published in print 18 January 1983. The author is extremely indebted to his colleagues and students, D. McQuitty, Y. Nishimura, D. Agar, M. Hjortso, J. Fazel-Madjlessi, M. Gilbert, A. Bartel, L. Y. Lee, and J. Oro, for their central role in the research described in this paper and to the National Science Foundation for financial support of this research.
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Series Name:ACS Symposium Series
Issue or Number:207
Record Number:CaltechAUTHORS:20180404-143706256
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Official Citation:Single-Cell Metabolic Model Determination by Analysis of Microbial Populations JAMES E. BAILEY Foundations of Biochemical Engineering. January 18, 1983 , 135-157 DOI:10.1021/bk-1983-0207.ch006
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85614
Deposited By: Ruth Sustaita
Deposited On:04 Apr 2018 21:45
Last Modified:15 Nov 2021 20:30

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