Mines, Gary A. and Winkler, Jay R. and Gray, Harry B. (1998) Spectroscopic Studies of Ferrocytochrome c Folding. In: Spectroscopic Methods in Bioinorganic Chemistry. ACS Symposium Series. No.692. American Chemical Society , Washington, DC, pp. 198-211. ISBN 9780841235601. https://resolver.caltech.edu/CaltechAUTHORS:20180406-091535617
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Abstract
Electron-transfer triggering has been employed in a comparison of the folding energetics and kinetics of cytochrome c from horse and Saccharomyces cerevisiae. These two proteins, with just 60% sequence identity but very similar backbone structures, fold at very different rates at a given denaturant concentration, but at nearly the same rate when their folding free energies are the same. Differences in the amino-acid sequences shift the position of the folding/unfolding equilibrium, but do not appear to alter the location of the transition state along the folding coordinate.
| Item Type: | Book Section | |||||||||
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| Additional Information: | © 1998 American Chemical Society. Published in print 9 June 1998. This work was supported by the National Science Foundation (MCB-9630465), the National Institutes of Health, and the Arnold and Mabel Beckman Foundation. | |||||||||
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| Series Name: | ACS Symposium Series | |||||||||
| Issue or Number: | 692 | |||||||||
| DOI: | 10.1021/bk-1998-0692.ch010 | |||||||||
| Record Number: | CaltechAUTHORS:20180406-091535617 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180406-091535617 | |||||||||
| Official Citation: | Spectroscopic Studies of Ferrocytochrome c Folding Gary A. Mines, Jay R. Winkler, and Harry B. Gray Spectroscopic Methods in Bioinorganic Chemistry. June 9, 1998, 198-211 DOI:10.1021/bk-1998-0692.ch010 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 85677 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 06 Apr 2018 17:42 | |||||||||
| Last Modified: | 15 Nov 2021 20:31 |
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