Small molecule based drug capture materials

Abstract

Direct delivery of chemotherapeutics to cancer cells has improved cancer treatment using methods such as chemoembolization. Unfortunately, some of the administered drugs leave the target cancer cells and enter the systemic circulation, causing serious side effects. To prevent these off-target chemotherapy effects, a variety of drug-filtering materials are being developed. For example, uses of ion exchange resins and DNA embedded on iron oxide nanoparticles have shown promising results. However, a key concern with DNA based materials is possible DNA fragmentation and unknown effects of foreign DNA fragments in the body. Therefore, development of drug filters with biol. benign material is crucial. In the present study, development of selective drug capture materials based on small mols. on metal or metal oxide surfaces will be discussed.