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Long-Range Electron Transfer in Biology

Winkler, Jay R. (2006) Long-Range Electron Transfer in Biology. In: Encyclopedia of Inorganic Chemistry. Wiley , Chichester. ISBN 9780470860786.

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Electron‐transfer processes are vital elements of energy transduction pathways in living cells. A unique synergy between theory and experiment has produced an extraordinarily detailed understanding of the factors that regulate this ‘current of life’. Studies of Ru‐modified proteins have provided insights into the distance‐ and driving‐force dependences of intraprotein electron transfer rates. Electron transfer across protein–protein interfaces has been probed both in solution and in structurally characterized crystals. It is now clear that electrons tunnel between sites in biological redox chains, and that protein structures tune thermodynamic properties and electronic coupling interactions to facilitate these reactions. This research has produced an experimentally validated, electron tunneling timetable that predicts the time required for an electron to transfer across a specified distance in a protein. Many of the electron tunneling rates measured in cytochrome c oxidase and photosynthetic reaction centers agree well with timetable predictions, indicating that the natural reactions are highly optimized, both in terms of thermodynamics and electronic coupling.

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Winkler, Jay R.0000-0002-4453-9716
Additional Information:© 2006 John Wiley & Sons, Ltd. Published Online: 15 March 2006.
Subject Keywords:electron transfer; electron tunneling; driving force; reorganization energy; protein; cytochrome c; cytochrome b5; cytochrome c peroxidase; azurin; cytochrome oxidase; photosynthetic reaction center
Record Number:CaltechAUTHORS:20180412-131138618
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Official Citation:Winkler, J. R. (2006). Long‐Range Electron Transfer in Biology. In Encyclopedia of Inorganic Chemistry (eds R. B. King, R. H. Crabtree, C. M. Lukehart, D. A. Atwood and R. A. Scott). doi:10.1002/0470862106.ia270
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85789
Deposited By: Tony Diaz
Deposited On:12 Apr 2018 20:21
Last Modified:15 Nov 2021 20:32

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