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O-GlcNAc glycosylation: From reductionism to systems biology

Hsieh-Wilson, Linda (2018) O-GlcNAc glycosylation: From reductionism to systems biology. In: 255th American Chemical Society National Meeting & Exposition, March 18-22, 2018, New Orleans, LA.

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The dynamic posttranslational modification of proteins by O-linked-β-N-acetylglucosamine (O-GlcNAc glycosylation) plays many important roles in physiol. and disease. Remarkably, only a single enzyme catalyzes the modification, raising the question of how this enzyme (O-GlcNAc transferase or OGT) selects from among its diverse substrates to regulate specific cellular processes. Here we will describe a new systems-level approach for studying the functions, specificity, and regulation of O-GlcNAc glycosylation. Elucidation of these dynamic O-glycosylation networks provides insights into the key functions of this modification and may reveal novel approaches for therapeutic intervention.

Item Type:Conference or Workshop Item (Paper)
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Hsieh-Wilson, Linda0000-0001-5661-1714
Additional Information:© 2018 American Chemical Society.
Record Number:CaltechAUTHORS:20180413-074121179
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85806
Deposited By: Tony Diaz
Deposited On:13 Apr 2018 16:21
Last Modified:03 Oct 2019 19:35

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