Hsieh-Wilson, Linda (2018) O-GlcNAc glycosylation: From reductionism to systems biology. In: 255th American Chemical Society National Meeting & Exposition, March 18-22, 2018, New Orleans, LA. https://resolver.caltech.edu/CaltechAUTHORS:20180413-074121179
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Abstract
The dynamic posttranslational modification of proteins by O-linked-β-N-acetylglucosamine (O-GlcNAc glycosylation) plays many important roles in physiol. and disease. Remarkably, only a single enzyme catalyzes the modification, raising the question of how this enzyme (O-GlcNAc transferase or OGT) selects from among its diverse substrates to regulate specific cellular processes. Here we will describe a new systems-level approach for studying the functions, specificity, and regulation of O-GlcNAc glycosylation. Elucidation of these dynamic O-glycosylation networks provides insights into the key functions of this modification and may reveal novel approaches for therapeutic intervention.
| Item Type: | Conference or Workshop Item (Paper) | ||||||
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| Additional Information: | © 2018 American Chemical Society. | ||||||
| Record Number: | CaltechAUTHORS:20180413-074121179 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180413-074121179 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 85806 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 13 Apr 2018 16:21 | ||||||
| Last Modified: | 03 Oct 2019 19:35 |
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