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Molecular recognition of DNA: From discovery to oncology

Kurmis, Alexis and Dervan, Peter (2018) Molecular recognition of DNA: From discovery to oncology. In: 255th American Chemical Society National Meeting & Exposition, March 18-22, 2018, New Orleans, LA.

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Pyrrole-imidazole polyamides are synthetic mols. programmed to read the DNA double helix by a set of simple chem. principles. These small mols. achieve affinities comparable to DNA-binding proteins and are cell permeable. Research efforts are focused on the modulation of gene expression pathways by disruption of transcription factor-DNA interfaces. The oversupply or overactivity of one or more transcription factors may be required for the survival, growth, and metastatic behavior of all human cancers. The efficacy of Py-Im polyamide oligomers targeted against therapy resistant prostate cancer xenografts will be discussed.

Item Type:Conference or Workshop Item (Paper)
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Dervan, Peter0000-0001-8852-7306
Additional Information:© 2018 American Chemical Society.
Record Number:CaltechAUTHORS:20180413-074454301
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85807
Deposited By: Tony Diaz
Deposited On:13 Apr 2018 17:30
Last Modified:03 Oct 2019 19:35

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