Kurmis, Alexis and Dervan, Peter (2018) Molecular recognition of DNA: From discovery to oncology. In: 255th American Chemical Society National Meeting & Exposition, March 18-22, 2018, New Orleans, LA. https://resolver.caltech.edu/CaltechAUTHORS:20180413-074454301
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Abstract
Pyrrole-imidazole polyamides are synthetic mols. programmed to read the DNA double helix by a set of simple chem. principles. These small mols. achieve affinities comparable to DNA-binding proteins and are cell permeable. Research efforts are focused on the modulation of gene expression pathways by disruption of transcription factor-DNA interfaces. The oversupply or overactivity of one or more transcription factors may be required for the survival, growth, and metastatic behavior of all human cancers. The efficacy of Py-Im polyamide oligomers targeted against therapy resistant prostate cancer xenografts will be discussed.
| Item Type: | Conference or Workshop Item (Paper) | ||||||
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| Additional Information: | © 2018 American Chemical Society. | ||||||
| Record Number: | CaltechAUTHORS:20180413-074454301 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180413-074454301 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 85807 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 13 Apr 2018 17:30 | ||||||
| Last Modified: | 03 Oct 2019 19:35 |
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