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Effect of optical aberrations on intraocular pressure measurements using a microscale optical implant in ex vivo rabbit eyes

Han, Samuel J. and Park, Haeri and Lee, Jeong Oen and Choo, Hyuck (2018) Effect of optical aberrations on intraocular pressure measurements using a microscale optical implant in ex vivo rabbit eyes. Journal of Biomedical Optics, 23 (4). Art. No. 047002. ISSN 1083-3668. http://resolver.caltech.edu/CaltechAUTHORS:20180416-143006166

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Abstract

Elevated intraocular pressure (IOP) is the only modifiable major risk factor of glaucoma. Recently, accurate and continuous IOP monitoring has been demonstrated in vivo using an implantable sensor based on optical resonance with remote optical readout to improve patient outcomes. Here, we investigate the relationship between optical aberrations of ex vivo rabbit eyes and the performance of the IOP sensor using a custom-built setup integrated with a Shack–Hartmann sensor. The sensor readouts became less accurate as the aberrations increased in magnitude, but they remained within the clinically acceptable range. For root-mean-square wavefront errors of 0.10 to 0.94  μm, the accuracy and the signal-to-noise ratio were 0.58  ±  0.32  mm Hg and 15.57  ±  4.85  dB, respectively.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/1.JBO.23.4.047002DOIArticle
https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-23/issue-04/047002/Effect-of-optical-aberrations-on-intraocular-pressure-measurements-using-a/10.1117/1.JBO.23.4.047002.full?SSO=1PublisherArticle
ORCID:
AuthorORCID
Choo, Hyuck0000-0002-8903-7939
Additional Information:© 2018 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 180037R received Jan. 18, 2018; accepted for publication Mar. 23, 2018; published online Apr. 12, 2018. This work was supported by the National Institutes of Health (No. EY024582) and the Heritage Medical Research Institute. The authors declare that there are no conflicts of interest related to this article. All ex vivo experiments were performed using the rabbit eyes enucleated in a FACTA Humane Certified facility (Pel-Freeze).
Group:Heritage Medical Research Institute
Funders:
Funding AgencyGrant Number
NIHEY024582
Heritage Medical Research InstituteUNSPECIFIED
Subject Keywords:medical devices; optics; aberration; light; glaucoma
Record Number:CaltechAUTHORS:20180416-143006166
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180416-143006166
Official Citation:Samuel J. Han, Haeri Park, Jeong Oen Lee, Hyuck Choo, "Effect of optical aberrations on intraocular pressure measurements using a microscale optical implant in ex vivo rabbit eyes," Journal of Biomedical Optics 23(4), 047002 (12 April 2018). https://doi.org/10.1117/1.JBO.23.4.047002
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:85882
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Apr 2018 21:46
Last Modified:16 Apr 2018 21:46

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