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Long-Range Electron Transfer in Biology

Winkler, Jay R. (2011) Long-Range Electron Transfer in Biology. In: Encyclopedia of Inorganic and Bioinorganic Chemistry. Wiley , Hoboken, NJ, pp. 1-12. ISBN 9781119951438. https://resolver.caltech.edu/CaltechAUTHORS:20180424-133025822

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Abstract

Electron‐transfer processes are vital elements of energy transduction pathways in living cells. A unique synergy between theory and experiment has produced an extraordinarily detailed understanding of the factors that regulate this ‘current of life’. Studies of Ru‐modified proteins have provided insights into the distance‐ and driving‐force dependences of intraprotein electron transfer rates. Electron transfer across protein–protein interfaces has been probed both in solution and in structurally characterized crystals. It is now clear that electrons tunnel between sites in biological redox chains, and that protein structures tune thermodynamic properties and electronic coupling interactions to facilitate these reactions. This research has produced an experimentally validated, electron tunneling timetable that predicts the time required for an electron to transfer across a specified distance in a protein. Many of the electron tunneling rates measured in cytochrome c oxidase and photosynthetic reaction centers agree well with timetable predictions, indicating that the natural reactions are highly optimized, both in terms of thermodynamics and electronic coupling.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/9781119951438.eibc0252DOIArticle
https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119951438.eibc0252PublisherArticle
ORCID:
AuthorORCID
Winkler, Jay R.0000-0002-4453-9716
Additional Information:© 2011 John Wiley & Sons, Ltd. Published Online: 15 December 2011. I thank Brian S. Leigh for assistance with the graphics. This research is supported by the National Science Foundation and the National Institutes of Health.
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Funding AgencyGrant Number
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Subject Keywords:electron transfer; electron tunneling; driving force; reorganization energy; protein; cytochrome c; cytochrome b_5; cytochrome c peroxidase; azurin; cytochrome oxidase; photosynthetic reaction center
Record Number:CaltechAUTHORS:20180424-133025822
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180424-133025822
Official Citation:Winkler, J. R. (2011). Long‐Range Electron Transfer in Biology. In Encyclopedia of Inorganic and Bioinorganic Chemistry, R. A. Scott (Ed.). doi:10.1002/9781119951438.eibc0252
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86023
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Apr 2018 17:38
Last Modified:03 Oct 2019 19:38

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