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Tube Expansion Deformation Enables In Situ Synchrotron X-ray Scattering Measurements during Extensional Flow-Induced Crystallization of Poly l-Lactide Near the Glass Transition

Ramachandran, Karthik and Miscioscia, Riccardo and De Filippo, Giovanni and Pandolfi, Giuseppe and Di Luccio, Tiziana and Kornfield, Julia A. (2018) Tube Expansion Deformation Enables In Situ Synchrotron X-ray Scattering Measurements during Extensional Flow-Induced Crystallization of Poly l-Lactide Near the Glass Transition. Polymers, 10 (3). Art. No. 288. ISSN 2073-4360. PMCID PMC6415077. https://resolver.caltech.edu/CaltechAUTHORS:20180430-101112370

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Abstract

Coronary Heart Disease (CHD) is one of the leading causes of death worldwide, claiming over seven million lives each year. Permanent metal stents, the current standard of care for CHD, inhibit arterial vasomotion and induce serious complications such as late stent thrombosis. Bioresorbable vascular scaffolds (BVSs) made from poly l-lactide (PLLA) overcome these complications by supporting the occluded artery for 3–6 months and then being completely resorbed in 2–3 years, leaving behind a healthy artery. The BVS that recently received clinical approval is, however, relatively thick (~150 µm, approximately twice as thick as metal stents ~80 µm). Thinner scaffolds would facilitate implantation and enable treatment of smaller arteries. The key to a thinner scaffold is careful control of the PLLA microstructure during processing to confer greater strength in a thinner profile. However, the rapid time scales of processing (~1 s) defy prediction due to a lack of structural information. Here, we present a custom-designed instrument that connects the strain-field imposed on PLLA during processing to in situ development of microstructure observed using synchrotron X-ray scattering. The connection between deformation, structure and strength enables processing–structure–property relationships to guide the design of thinner yet stronger BVSs


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3390/polym10030288DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415077PubMed CentralArticle
ORCID:
AuthorORCID
Ramachandran, Karthik0000-0003-1820-7555
Miscioscia, Riccardo0000-0001-6586-4182
Di Luccio, Tiziana0000-0001-8947-0655
Kornfield, Julia A.0000-0001-6746-8634
Additional Information:© 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). Received: 11 February 2018 / Revised: 4 March 2018 / Accepted: 6 March 2018 / Published: 8 March 2018. (This article belongs to the Special Issue Processing-Structure-Properties Relationships in Polymers) This research used resources of the Advanced Photon Source (APS), a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. The authors acknowledge all the staff at beamline 5-ID-D DND-CAT of the Advanced Photon Source (APS) at the Argonne National Laboratories, especially Steven Weigand and James Rix for their support before and during the synchrotron experiments. The authors acknowledge Mary Beth Kossuth at Abbott Vascular for providing the preforms. KR and TDL are very thankful to Giuseppe Nenna at ENEA for useful discussions on ray tracing calculations. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 691238, the Jacobs Institute for Molecular Engineering for Medicine at the California Institute of Technology, and the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number F31HL137308. Author Contributions: Karthik Ramachandran and Julia A. Kornfield designed research; Karthik Ramachandran, Riccardo Miscioscia, Giovanni De Filippo, Giuseppe Pandolfi and Tiziana Di Luccio performed research; Karthik Ramachandran, Riccardo Miscioscia, Tiziana Di Luccio and Julia A. Kornfield analyzed data; and Karthik Ramachandran, Riccardo Miscioscia, Tiziana Di Luccio and Julia A. Kornfield wrote the paper. The authors declare no conflict of interest.
Group:Jacobs Institute for Molecular Engineering for Medicine
Funders:
Funding AgencyGrant Number
Department of Energy (DOE)DE-AC02-06CH11357
Marie Curie Fellowship691238
Jacobs Institute for Molecular Engineering for MedicineUNSPECIFIED
NIH Postdocotral FellowshipF31HL137308
Subject Keywords:PLLA; bioresorbable vascular scaffolds; stretch blow molding; biaxial elongation; SAXS; WAXS
Issue or Number:3
PubMed Central ID:PMC6415077
Record Number:CaltechAUTHORS:20180430-101112370
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180430-101112370
Official Citation:Ramachandran, K.; Miscioscia, R.; Filippo, G.D.; Pandolfi, G.; Di Luccio, T.; Kornfield, J.A. Tube Expansion Deformation Enables In Situ Synchrotron X-ray Scattering Measurements during Extensional Flow-Induced Crystallization of Poly l-Lactide Near the Glass Transition. Polymers 2018, 10, 288.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86115
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Apr 2018 18:13
Last Modified:03 Oct 2019 19:39

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