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NMR evidence for specific intercalation of Δ-rh(phen)_2phi^(3+) in [d(GTCGAC)_2]

David, Sheila S. and Barton, Jacqueline K. (1993) NMR evidence for specific intercalation of Δ-rh(phen)_2phi^(3+) in [d(GTCGAC)_2]. Journal of the American Chemical Society, 115 (7). pp. 2984-2985. ISSN 0002-7863. doi:10.1021/ja00060a060. https://resolver.caltech.edu/CaltechAUTHORS:20180501-151531707

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Abstract

The anchoring of metal complexes in the major groove of DNA through intercalation has been increasingly useful in the shape-selective design of novel metal complexes which bind DNA with high sequence-selectivity. Toward that goal, direct structural information regarding this intercalative interaction is essential. Phenanthrenequinone diimine (phi) complexes of Rh(III) bind avidly (K_b 1 ≥ 10^7) to DNA by intercalation in the major groove. Here we report the first ^1H-NMR studies of Δ-rh(phen)_2phi^(3+) bound to an oligonucleotide. These studies provide direct structural evidence for specific intercalation by this octahedral complex in the major groove of DNA.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1021/ja00060a060DOIArticle
https://pubs.acs.org/doi/suppl/10.1021/ja00060a060PublisherSupporting Information
ORCID:
AuthorORCID
David, Sheila S.0000-0001-5873-7935
Barton, Jacqueline K.0000-0001-9883-1600
Alternate Title:NMR evidence for specific intercalation of .DELTA.-rh(phen)2.phi.3+ in [d(GTCGAC)2]
Additional Information:© 1993 American Chemical Society. Received December 15. 1992. We are grateful to the National Institutes of Health (GM33309 and an NRSA GM13861-03 to S.S.D.) for their financial support. In addition, we thank B. Imperiali for help in processing the NMR data.
Funders:
Funding AgencyGrant Number
NIHGM33309
NIH Predoctoral FellowshipGM13861-03
Issue or Number:7
DOI:10.1021/ja00060a060
Record Number:CaltechAUTHORS:20180501-151531707
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180501-151531707
Official Citation:NMR evidence for specific intercalation of .DELTA.-rh(phen)2.phi.3+ in [d(GTCGAC)2] Sheila S. David and Jacqueline K. Barton Journal of the American Chemical Society 1993 115 (7), 2984-2985 DOI: 10.1021/ja00060a060
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86175
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:02 May 2018 14:57
Last Modified:15 Nov 2021 20:36

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