Cook, Colin A. and Martinez-Camarillo, Juan C. and Yang, Qianhui and Scianmarello, Nicholas E. and Humayun, Mark S. and Tai, Yu-Chong (2018) Phototherapeutic contact lens for diabetic retinopathy. In: 2018 IEEE Micro Electro Mechanical Systems (MEMS). IEEE , Piscataway, NJ, pp. 62-65. ISBN 978-1-5386-4782-0. http://resolver.caltech.edu/CaltechAUTHORS:20180503-104340333
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Abstract
This paper reports on the first phototherapeutic “contact lens” to manage diabetic retinopathy by reducing retinal metabolism via suppression of rod cell dark current. The contact lens is composed of PDMS embedded with a ring of gaseous tritium light sources providing continuous illumination over the lifetime of the lens. Electroretinogram responses from rabbits demonstrate bioactivity of the lens, which is further explored in 1D simulations of retinal oxygenation. Tests in human eyes validate comfort, fit, and the Troxler neural adaptation effect. With oxygen transmissibility, DK/t, of 130 Fatt, the lens meets FDA guidelines for overnight wear and offers advantages of comfort and reliability.
| Item Type: | Book Section | |||||||||
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| Additional Information: | © 2018 IEEE. Thanks to the Transducer Research Foundation for providing financial support to attend the conference. Additional support provided by the Natural Sciences and Engineering Research Council of Canada. | |||||||||
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| Record Number: | CaltechAUTHORS:20180503-104340333 | |||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20180503-104340333 | |||||||||
| Official Citation: | C. A. Cook, J. C. Martinez-Camarillo, Q. Yang, N. E. Scianmarello, M. S. Humayun and Y. C. Tai, "Phototherapeutic contact lens for diabetic retinopathy," 2018 IEEE Micro Electro Mechanical Systems (MEMS), Belfast, United Kingdom, 2018, pp. 62-65. doi: 10.1109/MEMSYS.2018.8346482. URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8346482&isnumber=8346457 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 86207 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 03 May 2018 21:01 | |||||||||
| Last Modified: | 03 May 2018 21:01 |
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