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Phototherapeutic contact lens for diabetic retinopathy

Cook, Colin A. and Martinez-Camarillo, Juan C. and Yang, Qianhui and Scianmarello, Nicholas E. and Humayun, Mark S. and Tai, Yu-Chong (2018) Phototherapeutic contact lens for diabetic retinopathy. In: 2018 IEEE Micro Electro Mechanical Systems (MEMS). IEEE , Piscataway, NJ, pp. 62-65. ISBN 978-1-5386-4782-0. https://resolver.caltech.edu/CaltechAUTHORS:20180503-104340333

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Abstract

This paper reports on the first phototherapeutic “contact lens” to manage diabetic retinopathy by reducing retinal metabolism via suppression of rod cell dark current. The contact lens is composed of PDMS embedded with a ring of gaseous tritium light sources providing continuous illumination over the lifetime of the lens. Electroretinogram responses from rabbits demonstrate bioactivity of the lens, which is further explored in 1D simulations of retinal oxygenation. Tests in human eyes validate comfort, fit, and the Troxler neural adaptation effect. With oxygen transmissibility, DK/t, of 130 Fatt, the lens meets FDA guidelines for overnight wear and offers advantages of comfort and reliability.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/MEMSYS.2018.8346482DOIArticle
https://ieeexplore.ieee.org/document/8346482PublisherArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2018 IEEE. Thanks to the Transducer Research Foundation for providing financial support to attend the conference. Additional support provided by the Natural Sciences and Engineering Research Council of Canada.
Funders:
Funding AgencyGrant Number
Transducer Research FoundationUNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Record Number:CaltechAUTHORS:20180503-104340333
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180503-104340333
Official Citation:C. A. Cook, J. C. Martinez-Camarillo, Q. Yang, N. E. Scianmarello, M. S. Humayun and Y. C. Tai, "Phototherapeutic contact lens for diabetic retinopathy," 2018 IEEE Micro Electro Mechanical Systems (MEMS), Belfast, United Kingdom, 2018, pp. 62-65. doi: 10.1109/MEMSYS.2018.8346482. URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8346482&isnumber=8346457
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86207
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 May 2018 21:01
Last Modified:03 Oct 2019 19:40

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