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Connectivity of neuronal populations within and between areas of primate somatosensory cortex

Pálfi, E. and Zalányi, L. and Ashaber, M. and Palmer, C. and Kántor, O. and Roe, A. W. and Friedman, R. M. and Négyessy, L. (2018) Connectivity of neuronal populations within and between areas of primate somatosensory cortex. Brain Structure and Function, 223 (6). pp. 2949-2971. ISSN 1863-2661. http://resolver.caltech.edu/CaltechAUTHORS:20180503-144512471

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Abstract

Functions of the cerebral cortex emerge via interactions of horizontally distributed neuronal populations within and across areas. However, the connectional underpinning of these interactions is not well understood. The present study explores the circuitry of column-size cortical domains within the hierarchically organized somatosensory cortical areas 3b and 1 using tract tracing and optical intrinsic signal imaging (OIS). The anatomical findings reveal that feedforward connections exhibit high topographic specificity, while intrinsic and feedback connections have a more widespread distribution. Both intrinsic and inter-areal connections are topographically oriented across the finger representations. Compared to area 3b, the low clustering of connections and small cortical magnification factor supports that the circuitry of area 1 scaffolds a sparse functional representation that integrates peripheral information from a large area that is fed back to area 3b. Fast information exchange between areas is ensured by thick axons forming a topographically organized, reciprocal pathway. Moreover, the highest density of projecting neurons and groups of axon arborization patches corresponds well with the size and locations of the functional population response reported by OIS. The findings establish connectional motifs at the mesoscopic level that underpin the functional organization of the cerebral cortex.


Item Type:Article
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URLURL TypeDescription
https://doi.org/10.1007/s00429-018-1671-8DOIArticle
https://rdcu.be/1XFJPublisherFree ReadCube access
ORCID:
AuthorORCID
Négyessy, L.0000-0002-4369-0406
Additional Information:© Springer-Verlag GmbH Germany, part of Springer Nature 2018. Received: 10 November 2017; Accepted: 21 April 2018; First Online: 03 May 2018. Supported by the Fogarty International Research Collaboration Award, U.S. National Institutes of Health; Grant numbers: NS059061 (to A.W.R. and L.N.), NS044375 and NS093998 (to A.W.R.) as well as the Hungarian Scientific Research Fund; Grant number: OTKA NN79366 (to L.N.). The authors declare that they have no conflict of interest. This article does not contain any studies with human participants performed by any of the authors. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. Animal care and surgeries were performed according to NIH (National Institute of Health) regulations and were in compliance with and approved by the Institutional Animal Care and Use Committee of Vanderbilt University.
Funders:
Funding AgencyGrant Number
Fogarty International CenterUNSPECIFIED
NIHNS059061
NIHNS044375
NIHNS093998
Hungarian Scientific Research Fund (OTKA)OTKA NN79366
Subject Keywords:Horizontal connections · Cortical hierarchy · Cortical magnification · Optical intrinsic signal imaging · Tract tracing
Record Number:CaltechAUTHORS:20180503-144512471
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180503-144512471
Official Citation:Pálfi, E., Zalányi, L., Ashaber, M. et al. Brain Struct Funct (2018) 223: 2949. https://doi.org/10.1007/s00429-018-1671-8
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86215
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:03 May 2018 22:32
Last Modified:26 Jun 2018 22:09

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