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Long-Range Electron Transfer through DNA Films

Kelley, Shana O. and Jackson, Nicole M. and Hill, Michael G. and Barton, Jacqueline K. (1999) Long-Range Electron Transfer through DNA Films. Angewandte Chemie International Edition, 38 (7). pp. 941-945. ISSN 1433-7851. doi:10.1002/(SICI)1521-3773(19990401)38:7<941::AID-ANIE941>3.0.CO;2-7.

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Regardless of its position within the DNA film, cross‐linked daunomycin (DM) is efficiently reduced electrochemically, indicating that the electron transfer exhibits a shallow distance dependence. Upon the introduction of an intervening cytosine–adenine (CA) mismatch, the electrochemical response is dramatically attenuated (shown schematically). Therefore, the DNA double helix can facilitate long‐range electron transfer, but only in the presence of a well‐stacked pathway.

Item Type:Article
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URLURL TypeDescription<941::AID-ANIE941>3.0.CO;2-7DOIArticle
Kelley, Shana O.0000-0003-3360-5359
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1999 Wiley‐VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany. Issue Online 26 March 1999; Version of Record online: 26 March 1999; Manuscript received: 15 October 1998. We are grateful to the Camille and Henry Dreyfus Foundation (Faculty Start-up Grant to M.G.H.), the Research Corporation (M.G.H.), and the NIH (GM49216 to J.K.B., predoctoral traineeship to S.O.K.). In addition, we thank Dr. M. J. Allen for assistance with the AFM measurements, and Prof. F. C. Anson for helpful discussions.
Funding AgencyGrant Number
Camille and Henry Dreyfus FoundationUNSPECIFIED
Research CorporationUNSPECIFIED
Subject Keywords:Biosensors; Cyclic voltammetry; DNA structures; Electron transfer; Monolayers; Thin films
Issue or Number:7
Record Number:CaltechAUTHORS:20180507-111150983
Persistent URL:
Official Citation:Kelley, S. O., Jackson, N. M., Hill, M. G. and Barton, J. K. (1999), Long‐Range Electron Transfer through DNA Films. Angewandte Chemie International Edition, 38: 941-945. doi:10.1002/(SICI)1521-3773(19990401)38:7<941::AID-ANIE941>3.0.CO;2-7
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86245
Deposited By: Tony Diaz
Deposited On:07 May 2018 20:12
Last Modified:15 Nov 2021 20:36

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