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The Crystal Structure of a Potassium Channel — A New Era in the Chemistry of Biological Signaling

Dougherty, Dennis A. and Lester, Henry A. (1998) The Crystal Structure of a Potassium Channel — A New Era in the Chemistry of Biological Signaling. Angewandte Chemie International Edition, 37 (17). pp. 2329-2331. ISSN 1433-7851. https://resolver.caltech.edu/CaltechAUTHORS:20180508-083019710

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Abstract

The similarity to crown ethers is apparent when the arrangement of the oxygen atoms of the carbonyl groups of the protein backbone in the structure of the potassium channel (see schematic drawing of a section of the structure) found in the bacterium Streptomyces lividans is considered. This particular part of the channel pore acts as the selectivity filter, with the permeability of the channel for K+ being as much as 10 000 times greater than for the Na+ ion. In fact, in this area of the structure two K+ ions are located, a feature that enables high flux through the channel.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/(SICI)1521-3773(19980918)37:17<2329::AID-ANIE2329>3.0.CO;2-MDOIArticle
ORCID:
AuthorORCID
Dougherty, Dennis A.0000-0003-1464-2461
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 1998 Wiley‐VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany. Issue Online 17 December 1998; Version of Record online: 17 December 1998. We thank Professors Doug Rees (California Institute of Technology), Chris Miller (Brandeis), and Rod MacKinnon (Rockefeller) for helpful discussions. Our own work on K^+ channels and related structures is supported by the NIH (NS-34407 and GM 29836).
Funders:
Funding AgencyGrant Number
NIHNS-34407
NIHGM 29836
Subject Keywords:Ion channels; Membrane proteins; Protein structures; Signal transduction; Structure elucidation
Issue or Number:17
Record Number:CaltechAUTHORS:20180508-083019710
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180508-083019710
Official Citation:Dougherty, D. A. and Lester, H. A. (1998), The Crystal Structure of a Potassium Channel— A New Era in the Chemistry of Biological Signaling. Angewandte Chemie International Edition, 37: 2329-2331. doi:10.1002/(SICI)1521-3773(19980918)37:17<2329::AID-ANIE2329>3.0.CO;2-M
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86271
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 May 2018 16:02
Last Modified:03 Oct 2019 19:41

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