Fu, Gregory C. and Grubbs, Robert H. (1993) Synthesis of cycloalkenes via alkylidene-mediated olefin metathesis and carbonyl olefination. Journal of the American Chemical Society, 115 (9). pp. 3800-3801. ISSN 0002-7863. doi:10.1021/ja00062a066. https://resolver.caltech.edu/CaltechAUTHORS:20180514-160629402
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Abstract
The development of efficient methods for constructing carbocycles continues to be an important goal of synthetic organic chemistry. One extremely useful approach to the formation of unsaturated carbocycles is the intramolecular dicarbonyl coupling reaction (eq 1). Oftentimes, the substrate employed in this process is generated by oxidation of a diene or of an olefinic ketone. In this communication, we report that transition-metal alkylidenes effect the direct synthesis of unsaturated carbocycles from either of these precursors (eqs 2 and 3).
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| Additional Information: | © 1993 American Chemical Society. Received January 6, 1993. Support has been provided by the National Science Foundation (postdoctoral fellowship to G.C.F.) and the National Institutes of Health. We thank David Mai for technical assistance. | |||||||||
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| Issue or Number: | 9 | |||||||||
| DOI: | 10.1021/ja00062a066 | |||||||||
| Record Number: | CaltechAUTHORS:20180514-160629402 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180514-160629402 | |||||||||
| Official Citation: | Synthesis of cycloalkenes via alkylidene-mediated olefin metathesis and carbonyl olefination. Gregory C. Fu and Robert H. Grubbs. Journal of the American Chemical Society 1993 115 (9), 3800-3801. DOI: 10.1021/ja00062a066 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 86400 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 18 May 2018 18:28 | |||||||||
| Last Modified: | 15 Nov 2021 20:38 |
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