Dupureur, Cynthia M. and Barton, Jacqueline K. (1997) Structural Studies of Λ- and Δ-[Ru(phen)_2dppz]^(2+)Bound to d(GTCGAC)_2: Characterization of Enantioselective Intercalation. Inorganic Chemistry, 36 (1). pp. 33-43. ISSN 0020-1669. doi:10.1021/ic960738a. https://resolver.caltech.edu/CaltechAUTHORS:20180515-132544141
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Abstract
^1H and ^(31)P NMR have been applied in characterizing the enantioselective interactions between Λ- and Δ-[Ru(phen)_2dppz]^(2+) and the hexamer oligonucleotide d(GTCGAC)_2. Both isomers intercalate into the helix, and intermolecular NOEs place the Δ-isomer in the major groove. The NMR results indicate that Ru(phen)_2dppz^(2+) isomers bind to the DNA helix with a population of intercalative geometries and therefore extend earlier structural models based upon luminescence studies.
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| Additional Information: | © 1997 American Chemical Society. Received June 20, 1996. Publication Date (Web): January 1, 1997. We are grateful to the NIH (Grant GM33309) for their financial support of this work. In addition C.M.D. thanks the NSF for a postdoctoral fellowship. | |||||||||
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| Issue or Number: | 1 | |||||||||
| DOI: | 10.1021/ic960738a | |||||||||
| Record Number: | CaltechAUTHORS:20180515-132544141 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180515-132544141 | |||||||||
| Official Citation: | Structural Studies of Λ- and Δ-[Ru(phen)2dppz]2+ Bound to d(GTCGAC)2: Characterization of Enantioselective Intercalation. Cynthia M. Dupureur and Jacqueline K. Barton. Inorganic Chemistry 1997 36 (1), 33-43. DOI: 10.1021/ic960738a | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 86410 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 18 May 2018 18:17 | |||||||||
| Last Modified: | 15 Nov 2021 20:38 |
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