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Structural Studies of Λ- and Δ-[Ru(phen)_2dppz]^(2+)Bound to d(GTCGAC)_2: Characterization of Enantioselective Intercalation

Dupureur, Cynthia M. and Barton, Jacqueline K. (1997) Structural Studies of Λ- and Δ-[Ru(phen)_2dppz]^(2+)Bound to d(GTCGAC)_2: Characterization of Enantioselective Intercalation. Inorganic Chemistry, 36 (1). pp. 33-43. ISSN 0020-1669. https://resolver.caltech.edu/CaltechAUTHORS:20180515-132544141

[img] PDF (Contour plots of the base-H1‘ region of the NOESY spectrum of d(GTCGAC)2 in the absence and presence of Δ-[Ru(phen-d8)2dppz]2+ and a figure depicting the imino proton spectra of d(GTCGAC)2 upon titration with [Ru(phen)2dppz]2+ (4 pages)) - Supplemental Material
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Abstract

^1H and ^(31)P NMR have been applied in characterizing the enantioselective interactions between Λ- and Δ-[Ru(phen)_2dppz]^(2+) and the hexamer oligonucleotide d(GTCGAC)_2. Both isomers intercalate into the helix, and intermolecular NOEs place the Δ-isomer in the major groove. The NMR results indicate that Ru(phen)_2dppz^(2+) isomers bind to the DNA helix with a population of intercalative geometries and therefore extend earlier structural models based upon luminescence studies.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ic960738aDOIArticle
https://pubs.acs.org/doi/suppl/10.1021/ic960738aPublisherSupporting Information
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1997 American Chemical Society. Received June 20, 1996. Publication Date (Web): January 1, 1997. We are grateful to the NIH (Grant GM33309) for their financial support of this work. In addition C.M.D. thanks the NSF for a postdoctoral fellowship.
Funders:
Funding AgencyGrant Number
NIHGM33309
NSF Postdoctoral FellowshipUNSPECIFIED
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Record Number:CaltechAUTHORS:20180515-132544141
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180515-132544141
Official Citation:Structural Studies of Λ- and Δ-[Ru(phen)2dppz]2+ Bound to d(GTCGAC)2:  Characterization of Enantioselective Intercalation. Cynthia M. Dupureur and Jacqueline K. Barton. Inorganic Chemistry 1997 36 (1), 33-43. DOI: 10.1021/ic960738a
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86410
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 May 2018 18:17
Last Modified:03 Oct 2019 19:43

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