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Template-mediated synthesis of metal-complexing polymers for molecular recognition

Dhal, Pradeep K. and Arnold, Frances H. (1991) Template-mediated synthesis of metal-complexing polymers for molecular recognition. Journal of the American Chemical Society, 113 (19). pp. 7417-7418. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20180515-142255603

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Abstract

The design of synthetic molecules capable of recognizing given chemical entities in a specific and predictable manner is of great fundamental and practical importance. The principal paradigm of the molecular design of such materials involves the preorganization of binding sites of the host system (receptor) around complementary binding sites of the guest molecule (substrate). Wulff and co-workers devised a novel approach to synthesizing substrate-selective polymers that consists of covalent linking of polymerizable groups around a template molecule and subsequent cross-linking polymerization of the resulting assembly. The orientations of the binding sites of the template molecules sculpt the substrate-selective architecture of the templated polymers. Here we report a novel variation of this template polymerization technique to synthesize rigid macroporous polymers containing strategically distributed Cu(II)-iminodiacetate (Cu^(II)IDA) complexes. The resulting polymers exhibit selectivity for bisimidazole "protein analogues" that are not distinguishable by reverse-phase HPLC.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ja00019a046DOIArticle
https://pubs.acs.org/doi/suppl/10.1021/ja00019a046PublisherSupporting Information
ORCID:
AuthorORCID
Dhal, Pradeep K.0000-0002-7059-855X
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1991 American Chemical Society. Received May 9, 1991. F.H.A. gratefully acknowledges support from the National Science Foundation (PYI program) and a fellowship from the David and Lucile Packard Foundation.
Funders:
Funding AgencyGrant Number
NSFUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Issue or Number:19
Record Number:CaltechAUTHORS:20180515-142255603
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180515-142255603
Official Citation:Template-mediated synthesis of metal-complexing polymers for molecular recognition. Pradeep K. Dhal and Frances H. Arnold. Journal of the American Chemical Society 1991 113 (19), 7417-7418. DOI: 10.1021/ja00019a046
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86414
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 May 2018 18:09
Last Modified:03 Oct 2019 19:43

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