A Caltech Library Service

Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc

Walkup, Grant K. and Imperiali, Barbara (1996) Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc. Journal of the American Chemical Society, 118 (12). pp. 3053-3054. ISSN 0002-7863. doi:10.1021/ja9538501.

[img] PDF (Amino acid and peptide synthesis protocols and fluorescence emission assay data (5 pages)) - Supplemental Material
See Usage Policy.


Use this Persistent URL to link to this item:


The rapid analysis of trace metal cations for environmental and biomedical applications is particularly demanding since it requires the specific recognition of a particular element in the presence of numerous closely related species. While remarkable progress has been achieved for inorganic analytes, such as Ca^(2+), there is still a significant need for the genesis of new fluorosensors. In light of the selectivity and avidity with which proteins bind divalent metal cations, we have chosen to use a polypeptide architecture as the framework for metal ion recognition.In addition, our ability to manipulate synthetic polypeptides allows the coordinated integration of fluorescent reporters for signal transduction within a metal-binding peptidyl construct. Herein we report the design, synthesis, and evaluation of a selective fluorescent chemosensor, sensitive to nanomolar concentrations of Zn^(2+).

Item Type:Article
Related URLs:
URLURL TypeDescription Information
Additional Information:© 1996 American Chemical Society. Received November 16, 1995. Publication Date (Web): March 27, 1996. This research was supported by ONR, NSF, and the Caltech President's Fund. The award of a Glaxo Summer Fellowship (to G.K.W.) and a Camille and Henry Dreyfus Teacher Scholar Award (to B.I.) is also gratefully acknowledged.
Funding AgencyGrant Number
Office of Naval Research (ONR)UNSPECIFIED
Caltech President’s FundUNSPECIFIED
Glaxo Summer FellowshipUNSPECIFIED
Camille and Henry Dreyfus FoundationUNSPECIFIED
Issue or Number:12
Record Number:CaltechAUTHORS:20180515-155558284
Persistent URL:
Official Citation:Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc. Grant K. Walkup and and Barbara Imperiali. Journal of the American Chemical Society 1996 118 (12), 3053-3054. DOI: 10.1021/ja9538501
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86417
Deposited By: Tony Diaz
Deposited On:16 May 2018 16:50
Last Modified:15 Nov 2021 20:38

Repository Staff Only: item control page