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A brief history of COMBINE

Myers, Chris J. and Bader, Gary and Gleeson, Padraig and Golebiewski, Martin and Hucka, Michael and Le Novère, Nicolas and Nickerson, David P. and Schreiber, Falk and Waltemath, Dagmar (2017) A brief history of COMBINE. In: Proceedings of the 2017 Winter Simulation Conference. IEEE , Piscataway, NJ, pp. 884-895. ISBN 978-1-5386-3428-8.

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Standards for data exchange are critical to the development of any field. They enable researchers and practitioners to transport information reliably, to apply a variety of tools to their problems, and to reproduce scientific results. Over the past two decades, a range of standards have been developed to facilitate the exchange and reuse of information in the domain of representation and modeling of biological systems. These standards are complementary, so the interactions between their developers increased over time. By the end of the last decade, the community of researchers decided that more interoperability is required between the standards, and that common development is needed to make better use of effort, time, and money devoted to this activity. The COmputational MOdeling in Biology NEtwork (COMBINE) was created to enable the sharing of resources, tools, and other infrastructure. This paper provides a brief history of this endeavor and the challenges that remain.

Item Type:Book Section
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URLURL TypeDescription
Myers, Chris J.0000-0002-8762-8444
Hucka, Michael0000-0001-9105-5960
Le Novère, Nicolas0000-0002-6309-7327
Nickerson, David P.0000-0003-4667-9779
Waltemath, Dagmar0000-0002-5886-5563
Additional Information:© 2017 IEEE. CM is supported by the National Science Foundation under Grant No. CCF-1218095 and DBI-1356041. MH is supported by NIGMS award R01070923. GDB is supported by NHGRI award U41HG006623. NLN is supported by BBSRC grant BB/P013384/1. DPN is supported by the Aotearoa Foundation and NIGMS award P50-GM094503. MG is supported by the German Federal Ministry of Education and Research (BMBF) through the Liver Systems Medicine (LiSyM) project and was also supported by the German Federal Ministry for Economic Affairs and Energy (BMWi) through the NormSys project (FKZ 01FS14019). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NSF or our other funding agencies.
Funding AgencyGrant Number
Biotechnology and Biological Sciences Research Council (BBSRC)BB/P013384/1
Aotearoa FoundationUNSPECIFIED
Bundesministerium für Bildung und Forschung (BMBF)UNSPECIFIED
Bundesministerium für Wirtschaft und Energie (BMWi)FKZ 01FS14019
National Human Genome Research InstituteUNSPECIFIED
Record Number:CaltechAUTHORS:20180516-143900255
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Official Citation:C. J. Myers et al., "A brief history of COMBINE," 2017 Winter Simulation Conference (WSC), Las Vegas, NV, 2017, pp. 884-895. doi: 10.1109/WSC.2017.8247840. URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86428
Deposited By: Tony Diaz
Deposited On:18 May 2018 17:21
Last Modified:09 Mar 2020 13:19

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