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Exploiting Polypeptide Motifs for the Design of Selective Cu(II) Ion Chemosensors

Torrado, Alicia and Walkup, Grant K. and Imperiali, Barbara (1998) Exploiting Polypeptide Motifs for the Design of Selective Cu(II) Ion Chemosensors. Journal of the American Chemical Society, 120 (3). pp. 609-610. ISSN 0002-7863. doi:10.1021/ja973357k.

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The production of fluorescent devices for the sensing and reporting of chemical events is currently of significant importance for both chemistry and biology. More specifically, sensors directed toward the detection and measurement divalent copper have enjoyed particular attention. Our focus has been on the production of robust, small-molecule chemosensors that exhibit reversible signaling and operate in aqueous solution at neutral pH, without the requirement for organic cosolvents. Because the intended use for such a sensor is ultimately for the measurement of environmental or biological samples, sufficient detection selectivity is of prime concern to ensure that a measurement in the appropriate concentration range can be made, even in the presence of elevated levels of competing divalent cations.

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Additional Information:© 1998 American Chemical Society. Received September 25, 1997; Revised Manuscript Received November 26, 1997. Publication Date (Web): January 7, 1998. We thank Dr. M. Meldal of the Carlsberg Laboratory, Department of Chemistry, for the generous gift of PEGA-1900. This research was supported by the NSF and the Gates Foundation. The award of a NIH pre-doctoral training grant in biology and chemistry to G.K.W. (GM07616) and postdoctoral fellowships from NATO and Xunta de Galicia (to A.T.) are also gratefully acknowledged.
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Gates FoundationUNSPECIFIED
NIH Predoctoral FellowshipGM07616
North Atlantic Treaty Organization (NATO)UNSPECIFIED
Xunta de GaliciaUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20180517-151516068
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Official Citation:Exploiting Polypeptide Motifs for the Design of Selective Cu(II) Ion Chemosensors. Alicia Torrado, Grant K. Walkup, and Barbara Imperiali. Journal of the American Chemical Society 1998 120 (3), 609-610. DOI: 10.1021/ja973357k
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86443
Deposited By: Tony Diaz
Deposited On:18 May 2018 17:00
Last Modified:15 Nov 2021 20:38

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