A Caltech Library Service

Argonaute Proteins and Mechanisms of RNA Interference in Eukaryotes and Prokaryotes

Olina, A. V. and Kulbachinskiy, A. V. and Aravin, A. A. and Esyunina, D. M. (2018) Argonaute Proteins and Mechanisms of RNA Interference in Eukaryotes and Prokaryotes. Biochemistry (Moscow), 83 (5). pp. 483-497. ISSN 0006-2979. doi:10.1134/S0006297918050024.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Noncoding RNAs play essential roles in genetic regulation in all organisms. In eukaryotic cells, many small non-coding RNAs act in complex with Argonaute proteins and regulate gene expression by recognizing complementary RNA targets. The complexes of Argonaute proteins with small RNAs also play a key role in silencing of mobile genetic elements and, in some cases, viruses. These processes are collectively called RNA interference. RNA interference is a powerful tool for specific gene silencing in both basic research and therapeutic applications. Argonaute proteins are also found in prokaryotic organisms. Recent studies have shown that prokaryotic Argonautes can also cleave their target nucleic acids, in particular DNA. This activity of prokaryotic Argonautes might potentially be used to edit eukaryotic genomes. However, the molecular mechanisms of small nucleic acid biogenesis and the functions of Argonaute proteins, in particular in bacteria and archaea, remain largely unknown. Here we briefly review available data on the RNA interference processes and Argonaute proteins in eukaryotes and prokaryotes.

Item Type:Article
Related URLs:
URLURL TypeDescription ReadCube access
Additional Information:© 2018 Pleiades Publishing, Ltd. Received November 8, 2017; Revision received December 5, 2017; First Online: 19 May 2018. This work was supported by the Russian Science Foundation (grant 16-14-10377).
Funding AgencyGrant Number
Russian Science Foundation16-14-10377
Subject Keywords:Argonaute proteins; RNA interference; small RNAs; mobile genetic elements
Issue or Number:5
Record Number:CaltechAUTHORS:20180521-094519332
Persistent URL:
Official Citation:Olina, A.V., Kulbachinskiy, A.V., Aravin, A.A. et al. Biochemistry Moscow (2018) 83: 483.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86493
Deposited By: Tony Diaz
Deposited On:21 May 2018 17:34
Last Modified:15 Nov 2021 20:39

Repository Staff Only: item control page