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A Calcium-Sensitive Magnetic Resonance Imaging Contrast Agent

Li, Wen-hong and Fraser, Scott E. and Meade, Thomas J. (1999) A Calcium-Sensitive Magnetic Resonance Imaging Contrast Agent. Journal of the American Chemical Society, 121 (6). pp. 1413-1414. ISSN 0002-7863. doi:10.1021/ja983702l.

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Ca^(2+) is an important intracellular secondary messenger of signal transduction. Changes in the cytosolic concentration of Ca^(2+) trigger changes in cellular metabolism and are responsible for cell signaling and regulation. Advances in optical microscopy techniques and improvements in fluorescent dyes capable of measuring Ca^(2+) concentration have added greatly to the understanding of the critical role this ion plays in cell and neurobiology. However, a fundamental limitation of light-based microscope imaging techniques employing dyes or fluorochromes is that they produce toxic photobleaching byproducts and are limited by light scattering to those cells within 100 µm of the surface. Magnetic resonance imaging (MRI) of biological structures provides an alternative to light-based microscopy that can circumvent these limitations. Recent work in this area has demonstrated the feasibility of true three-dimensional MR imaging at cellular resolution (~10 µm).

Item Type:Article
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Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 1999 American Chemical Society. Publication Date (Web): January 29, 1999. This work was supported by the Biological Imaging Center of the Beckman Institute and the Human Brain Project with contributions from the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Science Foundation.
Funding AgencyGrant Number
Caltech Beckman InstituteUNSPECIFIED
Human Brain ProjectUNSPECIFIED
National Institute on Drug AbuseUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20180521-141013911
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Official Citation:A Calcium-Sensitive Magnetic Resonance Imaging Contrast Agent. Wen-hong Li, Scott E. Fraser, and Thomas J. Meade. Journal of the American Chemical Society 1999 121 (6), 1413-1414. DOI: 10.1021/ja983702l
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86511
Deposited By: Tony Diaz
Deposited On:21 May 2018 21:20
Last Modified:15 Nov 2021 20:39

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