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Sensing DNA through DNA Charge Transport

Zwang, Theodore J. and Tse, Edmund C. M. and Barton, Jacqueline K. (2018) Sensing DNA through DNA Charge Transport. ACS Chemical Biology, 13 (7). pp. 1799-1809. ISSN 1554-8929. PMCID PMC6080280. doi:10.1021/acschembio.8b00347. https://resolver.caltech.edu/CaltechAUTHORS:20180524-092613150

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Abstract

DNA charge transport chemistry involves the migration of charge over long molecular distances through the aromatic base pair stack within the DNA helix. This migration depends upon the intimate coupling of bases stacked one with another, and hence any perturbation in that stacking, through base modifications or protein binding, can be sensed electrically. In this review, we describe the many ways DNA charge transport chemistry has been utilized to sense changes in DNA, including the presence of lesions, mismatches, DNA-binding proteins, protein activity, and even reactions under weak magnetic fields. Charge transport chemistry is remarkable in its ability to sense the integrity of DNA.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acschembio.8b00347DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080280PubMed CentralArticle
ORCID:
AuthorORCID
Tse, Edmund C. M.0000-0002-9313-1290
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2018 American Chemical Society. Special Issue: Sensors. Received: April 16, 2018; Accepted: May 23, 2018; Published: May 23, 2018. We are grateful to all our co-workers and collaborators for their efforts in developing new sensing technologies. We also thank the NIH, GM61077, for financial support. E.C.M.T. acknowledges a Croucher Foundation Fellowship. The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
NIHGM61077
Croucher FoundationUNSPECIFIED
Issue or Number:7
PubMed Central ID:PMC6080280
DOI:10.1021/acschembio.8b00347
Record Number:CaltechAUTHORS:20180524-092613150
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180524-092613150
Official Citation:Sensing DNA through DNA Charge Transport. Theodore J. Zwang, Edmund C. M. Tse, and Jacqueline K. Barton. ACS Chemical Biology 2018 13 (7), 1799-1809. DOI: 10.1021/acschembio.8b00347
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86583
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 May 2018 16:31
Last Modified:15 Nov 2021 20:40

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