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Future systems and control research in synthetic biology

Del Vecchio, Domitilla and Qian, Yili and Murray, Richard M. and Sontag, Eduardo D. (2018) Future systems and control research in synthetic biology. Annual Reviews in Control, 45 . pp. 5-17. ISSN 1367-5788. doi:10.1016/j.arcontrol.2018.04.007.

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Synthetic biology is the application of engineering principles to the fundamental components of biology, with the aim of creating systems with novel functionalities that can be used for energy, environment, and medical applications. While the potential impact of this new technology is enormous, there are challenges that we need to overcome before the impact of synthetic biology can be fully realized. Many of these challenges fall beyond the scope of molecular biology and are indeed “system-level” problems, where very little research is being performed. This paper identifies pressing challenges in synthetic biology that can be formulated as systems and control theoretic problems and outlines potentially new systems and control theories/tools that are required to tackle such problems. The aim is to attract more systems and control theorists to collaborate with molecular biologists and biophysicists and help synthetic biology reach its promise. At the same time, engaging the systems and control community more broadly into the rich research opportunities and life-changing applications of synthetic biology may provide added visibility to the field of systems and controls.

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Murray, Richard M.0000-0002-5785-7481
Additional Information:© 2018 Elsevier Ltd. Received 16 February 2018, Revised 20 April 2018, Accepted 20 April 2018, Available online 24 May 2018.
Record Number:CaltechAUTHORS:20180525-123941302
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Official Citation:Domitilla Del Vecchio, Yili Qian, Richard M. Murray, Eduardo D. Sontag, Future systems and control research in synthetic biology, Annual Reviews in Control, Volume 45, 2018, Pages 5-17, ISSN 1367-5788, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86627
Deposited By: Tony Diaz
Deposited On:25 May 2018 19:49
Last Modified:15 Nov 2021 20:40

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