Kwong, Daniel W. J. and Chan, O. Y. and Wong, Ricky N. S. and Musser, Siegfried M. and Vaca, Luis and Chan, Sunney I. (1997) DNA-Photocleavage Activities of Vanadium(V)−Peroxo Complexes. Inorganic Chemistry, 36 (7). pp. 1276-1277. ISSN 0020-1669. doi:10.1021/ic960909b. https://resolver.caltech.edu/CaltechAUTHORS:20180529-114153019
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Abstract
The DNA-photocleavage activities (at 365 nm) of 15 vanadium(V)−peroxo complexes were examined. Singlet oxygen was implicated as the species responsible for the DNA scission. The singlet oxygen was shown to be produced from the photolysis of the vanadium(V)−peroxo complex using a singlet oxygen EPR spin trap, 2,2,6,6-tetramethyl-4-piperidone. A mechanism for the photolysis of the [VO(O_2)_2(bpy)]- anion at neutral pH has been proposed.
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| Additional Information: | © 1997 American Chemical Society. Received August 1, 1996. We gratefully acknowledge the financial support of the Hong Kong Baptist University Faculty Research Grants (FRG/93-94/II-68; to D.W.J.K.), the Hong Kong Research Grants Council (HKBC 153/95P; to D.W.J.K.), and the National Institute of General Medical Sciences, U.S. Public Health Service (GM22432; to S.I.C.). S.M.M. is a recipient of a National Research Service Predoctoral Award from the National Institute of General Medical Services. | ||||||||||
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| Issue or Number: | 7 | ||||||||||
| DOI: | 10.1021/ic960909b | ||||||||||
| Record Number: | CaltechAUTHORS:20180529-114153019 | ||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180529-114153019 | ||||||||||
| Official Citation: | DNA-Photocleavage Activities of Vanadium(V)−Peroxo Complexes Daniel W. J. Kwong, O. Y. Chan, Ricky N. S. Wong, Siegfried M. Musser, Luis Vaca, and Sunney I. Chan Inorganic Chemistry 1997 36 (7), 1276-1277 DOI: 10.1021/ic960909b | ||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
| ID Code: | 86668 | ||||||||||
| Collection: | CaltechAUTHORS | ||||||||||
| Deposited By: | George Porter | ||||||||||
| Deposited On: | 29 May 2018 20:12 | ||||||||||
| Last Modified: | 15 Nov 2021 20:40 |
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