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DNA-Photocleavage Activities of Vanadium(V)−Peroxo Complexes

Kwong, Daniel W. J. and Chan, O. Y. and Wong, Ricky N. S. and Musser, Siegfried M. and Vaca, Luis and Chan, Sunney I. (1997) DNA-Photocleavage Activities of Vanadium(V)−Peroxo Complexes. Inorganic Chemistry, 36 (7). pp. 1276-1277. ISSN 0020-1669. https://resolver.caltech.edu/CaltechAUTHORS:20180529-114153019

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Abstract

The DNA-photocleavage activities (at 365 nm) of 15 vanadium(V)−peroxo complexes were examined. Singlet oxygen was implicated as the species responsible for the DNA scission. The singlet oxygen was shown to be produced from the photolysis of the vanadium(V)−peroxo complex using a singlet oxygen EPR spin trap, 2,2,6,6-tetramethyl-4-piperidone. A mechanism for the photolysis of the [VO(O_2)_2(bpy)]- anion at neutral pH has been proposed.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1021/ic960909bDOIArticle
ORCID:
AuthorORCID
Chan, Sunney I.0000-0002-5348-2723
Additional Information:© 1997 American Chemical Society. Received August 1, 1996. We gratefully acknowledge the financial support of the Hong Kong Baptist University Faculty Research Grants (FRG/93-94/II-68; to D.W.J.K.), the Hong Kong Research Grants Council (HKBC 153/95P; to D.W.J.K.), and the National Institute of General Medical Sciences, U.S. Public Health Service (GM22432; to S.I.C.). S.M.M. is a recipient of a National Research Service Predoctoral Award from the National Institute of General Medical Services.
Funders:
Funding AgencyGrant Number
Hong Kong Baptist UniversityFRG/93-94/II-68
Hong Kong Research Grant CouncilHKBC 153/95P
NIHGM22432
NIH Predoctoral FellowshipUNSPECIFIED
Issue or Number:7
Record Number:CaltechAUTHORS:20180529-114153019
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180529-114153019
Official Citation:DNA-Photocleavage Activities of Vanadium(V)−Peroxo Complexes Daniel W. J. Kwong, O. Y. Chan, Ricky N. S. Wong, Siegfried M. Musser, Luis Vaca, and Sunney I. Chan Inorganic Chemistry 1997 36 (7), 1276-1277 DOI: 10.1021/ic960909b
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86668
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:29 May 2018 20:12
Last Modified:03 Oct 2019 19:46

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