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Assembly of DNA recognition elements on an octahedral rhodium intercalator: predictive recognition of 5'-TGCA-3' by Δ-[Rh[(R,R)-Me_2trien]phi]^(3+)

Krotz, Achim H. and Hudson, Brian P. and Barton, Jacqueline K. (1993) Assembly of DNA recognition elements on an octahedral rhodium intercalator: predictive recognition of 5'-TGCA-3' by Δ-[Rh[(R,R)-Me_2trien]phi]^(3+). Journal of the American Chemical Society, 115 (26). pp. 12577-12578. ISSN 0002-7863. doi:10.1021/ja00079a044. https://resolver.caltech.edu/CaltechAUTHORS:20180529-143627642

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Abstract

Here we explore the de novo design of rhodium intercalators for predictive four base pair recognition of duplex DNA. Complexes have been constructed which, like DNA-binding proteins, pose several functionalities for site-specific noncovalent interaction with DNA. Octahedral rhodium intercalators are particularly useful in this design since (i) the octahedral coordination specifies the stereochemistry of ligand functionalities and (ii) the intercalating ligands orients these functionalities with respect to the DNA major groove.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1021/ja00079a044DOIArticle
https://pubs.acs.org/doi/suppl/10.1021/ja00079a044PublisherSupporting Information
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Alternate Title:Assembly of DNA recognition elements on an octahedral rhodium intercalator: predictive recognition of 5'-TGCA-3' by .DELTA.-[Rh[(R,R)-Me2trien]phi]3+
Additional Information:© 1993 American Chemical Society. Received August 9, 1993. We are grateful to the National Institutes of Health (GM33309) for their financial support. In addition we thank the Deutsche Forschungsgemeinschaft (A.H.K.) for postdoctoral and the National Science Foundation (B.P.H.) for predoctoral fellowships.
Funders:
Funding AgencyGrant Number
NIHGM33309
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
NSF Predoctoral FellowshipUNSPECIFIED
Issue or Number:26
DOI:10.1021/ja00079a044
Record Number:CaltechAUTHORS:20180529-143627642
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180529-143627642
Official Citation:Assembly of DNA recognition elements on an octahedral rhodium intercalator: predictive recognition of 5'-TGCA-3' by .DELTA.-[Rh[(R,R)-Me2trien]phi]3+ Achim H. Krotz, Brian P. Hudson, and Jacqueline K. Barton Journal of the American Chemical Society 1993 115 (26), 12577-12578 DOI: 10.1021/ja00079a044
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86678
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:29 May 2018 21:47
Last Modified:15 Nov 2021 20:41

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