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Enantiospecific palindromic recognition of 5'-d(CTCTAGAG)-3' by a novel rhodium intercalator: analogies to a DNA-binding protein

Sitlani, Ayesha and Dupureur, Cynthia M. and Barton, Jacqueline K. (1993) Enantiospecific palindromic recognition of 5'-d(CTCTAGAG)-3' by a novel rhodium intercalator: analogies to a DNA-binding protein. Journal of the American Chemical Society, 115 (26). pp. 12589-12590. ISSN 0002-7863. doi:10.1021/ja00079a050. https://resolver.caltech.edu/CaltechAUTHORS:20180529-144212315

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Abstract

We are exploring principles of protein-DNA recognition through the design of model 9,10-phenanthrenequinonediimine (phi) complexes of rhodium(II1) which bind site-selectively to DNA. [Rh(phi)]^(3+) complexes intercalate in the DNA major groove through the phi ligand and upon photoactivation promote strand scission via abstraction of the deoxyribose C3‘-H atom. Here we report on the metal complex [Rh(DPB)_2phi]^(3+) (DPB = 4,4’-diphenyl-2,2’-bipyridyl) (Figure 1 ), which mimics DNA-binding proteins in DNA site-specificity and affinity.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1021/ja00079a050DOIArticle
https://pubs.acs.org/doi/suppl/10.1021/ja00079a050PublisherSupporting Information
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1993 American Chemical Society. Received July 2, 1993. Revised Manuscript Received November 6, 1993. We are grateful to the NIH (GM33309) for their financial support and to the NSF for a postdoctoral fellowship (C. M.D.).
Funders:
Funding AgencyGrant Number
NIHGM33309
NSF Postdoctoral FellowshipUNSPECIFIED
Issue or Number:26
DOI:10.1021/ja00079a050
Record Number:CaltechAUTHORS:20180529-144212315
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180529-144212315
Official Citation:Enantiospecific palindromic recognition of 5'-d(CTCTAGAG)-3' by a novel rhodium intercalator: analogies to a DNA-binding protein Ayesha Sitlani, Cynthia M. Dupureur, and Jacqueline K. Barton Journal of the American Chemical Society 1993 115 (26), 12589-12590 DOI: 10.1021/ja00079a050
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86679
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:29 May 2018 22:32
Last Modified:15 Nov 2021 20:41

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