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Chemical Probe for Glycosidic Conformation in Telomeric DNAs

Dias, Eric and Battiste, John L. and Williamson, James R. (1994) Chemical Probe for Glycosidic Conformation in Telomeric DNAs. Journal of the American Chemical Society, 116 (10). pp. 4479-4480. ISSN 0002-7863.

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Chemical modifications are powerful tools to probe nucleic acid structure and protein-nucleic acid interactions. Nucleic acids can be modified either randomly by a variety of chemical reagents or site-specifically with synthetic base analog substitutions. We report here the use of 8-bromodeoxyguanosine (8-Br-dG) as a modification that is directly sensitive to a dihedral angle. 8-Br-dG should prove useful as a chemical probe for the conformation about glycosidic bonds in unusual nucleic acid structures.

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Additional Information:© 1994 American Chemical Society. Received December 8, 1993. The authors wish to thank B. Wang for the mass spectral analysis, performed at the MIT Mass Spectrometry Resource, supported by the NIH (RR-00317, to K. Biemann), and Julius Rebek for comments on the manuscript. J.L.B. was supported by the NIH Interdepartmental Biotechnology Program (GM-08334). This work was supported by grants from the NIH (GM-46314), Pfizer, Inc., and the Searle Scholars Program of the Chicago Community Trust.
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Searle Scholars ProgramUNSPECIFIED
Issue or Number:10
Record Number:CaltechAUTHORS:20180529-162858475
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Official Citation:Chemical Probe for Glycosidic Conformation in Telomeric DNAs Eric Dias, John L. Battiste, and James R. Williamson Journal of the American Chemical Society 1994 116 (10), 4479-4480 DOI: 10.1021/ja00089a048
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:86695
Deposited By: George Porter
Deposited On:30 May 2018 14:58
Last Modified:03 Oct 2019 19:47

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